Kanarek R B, Glick A L, Marks-Kaufman R
Department of Psychology, Tufts University, Medford, MA 02155.
Physiol Behav. 1991 Jan;49(1):149-52. doi: 10.1016/0031-9384(91)90246-k.
The effects of acute administration of d-amphetamine sulfate (0.0, 0.5, 1.0 and 2.0 mg/kg) and dl-fenfluramine hydrochloride (0.0, 1.5, 3.0 and 6.0 mg/kg) on food intake were examined in male Sprague-Dawley rats fed either a high-carbohydrate diet (carbohydrate equaled 65% of total calories) or a high-fat diet (fat equaled 65% of total calories). Animals were given ad lib access to the diets throughout the experiment. Drug injections were given at 0900 on experimental days and food intakes were measured at 1, 3 and 6 h postinjection. Amphetamine led to dose-related decreases in food intake for animals on both diets. The effects of amphetamine were most noticeable at 1 and 3 h postinjection. No differences in amphetamine's effects on food intake were found as a function of diet. Fenfluramine injections also led to dose-related reductions in food intake for animals in both dietary conditions. In contrast to amphetamine, however, fenfluramine led to greater reductions in food intake for rats fed the high-fat diet than for rats fed the high-carbohydrate diet. These data demonstrate that dietary variables must be considered when evaluating the anorectic actions of psychopharmacological agents.
在喂食高碳水化合物饮食（碳水化合物占总热量的65%）或高脂肪饮食（脂肪占总热量的65%）的雄性斯普拉格-道利大鼠中，研究了急性给予硫酸右旋苯丙胺（0.0、0.5、1.0和2.0毫克/千克）和盐酸右芬氟拉明（0.0、1.5、3.0和6.0毫克/千克）对食物摄入量的影响。在整个实验过程中，动物可随意进食这些饮食。在实验日的09:00进行药物注射，并在注射后1、3和6小时测量食物摄入量。苯丙胺导致两种饮食的动物食物摄入量出现剂量相关的减少。苯丙胺的作用在注射后1和3小时最为明显。未发现苯丙胺对食物摄入量的影响因饮食不同而有差异。右芬氟拉明注射也导致两种饮食条件下的动物食物摄入量出现剂量相关的减少。然而，与苯丙胺不同的是，右芬氟拉明导致喂食高脂肪饮食的大鼠比喂食高碳水化合物饮食的大鼠食物摄入量减少得更多。这些数据表明，在评估精神药理学药物的厌食作用时，必须考虑饮食变量。
