Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Anal Bioanal Chem. 2010 Jun;397(4):1397-415. doi: 10.1007/s00216-010-3481-6. Epub 2010 Feb 20.
Quantum dots (QDs), also named semiconductor nanocrystals, have initiated a new realm of bioscience by combining nanomaterials with biology, which will profoundly influence future biological and biomedical research. In this review, we describe the extraordinary optical properties of QDs and developments in methods for their synthesis. We focus on fluorescent imaging with QDs both in vitro and in vivo, and the cytotoxicity of QDs and potential barriers to their use in practical biomedical applications. Finally, we provide insights into improvements aimed at decreasing the cytotoxicity of QDs and the future outlook of QD applications in biomedical fields.
量子点（QDs），也称为半导体纳米晶体，通过将纳米材料与生物学相结合，开创了生物科学的新纪元，这将深刻影响未来的生物和生物医学研究。在这篇综述中，我们描述了 QDs 的非凡光学性质和它们的合成方法的发展。我们专注于 QDs 的体外和体内荧光成像，以及 QDs 的细胞毒性和它们在实际生物医学应用中的潜在障碍。最后，我们提供了一些见解，旨在降低 QDs 的细胞毒性，并展望 QD 在生物医学领域的应用前景。
