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CTCF通过多种机制塑造染色质：20年CTCF研究对理解染色质运作机制的影响。

CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin.

作者信息

Ohlsson Rolf, Bartkuhn Marek, Renkawitz Rainer

机构信息

Institute for Microbiology, Tumor- and Cellbiology, Karolinska Institute, Stockholm, Sweden.

出版信息

Chromosoma. 2010 Aug;119(4):351-60. doi: 10.1007/s00412-010-0262-0. Epub 2010 Feb 20.

DOI:10.1007/s00412-010-0262-0
PMID:20174815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2910314/
Abstract

More than 10(9) base pairs of the genome in higher eucaryotes are positioned in the interphase nucleus such that gene activation, gene repression, remote gene regulation by enhancer elements, and reading as well as adjusting epigenetic marks are possible. One important structural and functional component of chromatin organization is the zinc finger factor CTCF. Two decades of research has advanced the understanding of the fundamental role that CTCF plays in regulating such a vast expanse of DNA.

摘要

高等真核生物基因组中超过10⁹个碱基对定位于间期细胞核中，从而使得基因激活、基因抑制、增强子元件的远程基因调控以及表观遗传标记的读取和调整成为可能。染色质组织的一个重要结构和功能成分是锌指因子CTCF。二十年的研究增进了我们对CTCF在调控如此大片段DNA中所起基本作用的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8c/2910314/ccd207401da9/412_2010_262_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8c/2910314/9faa4d00a752/412_2010_262_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8c/2910314/ccd207401da9/412_2010_262_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8c/2910314/9faa4d00a752/412_2010_262_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8c/2910314/ccd207401da9/412_2010_262_Fig2_HTML.jpg

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Genes Dev. 2009 Nov 15;23(22):2598-603. doi: 10.1101/gad.552109.
2
Chromosome crosstalk in three dimensions.三维染色体串扰
Nature. 2009 Sep 10;461(7261):212-7. doi: 10.1038/nature08453.
3
What controls nucleosome positions?是什么控制着核小体的位置？
早期适应性染色质重塑事件先于病理表型出现，并在衰竭心脏中得到加强。
J Mol Cell Cardiol. 2021 Nov;160:73-86. doi: 10.1016/j.yjmcc.2021.07.002. Epub 2021 Jul 15.
4
Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes.术后腹部脓毒症诱导人类单核细胞 MHC-II 区域内 CTCF 结合的选择性和持久性变化。
PLoS One. 2021 May 3;16(5):e0250818. doi: 10.1371/journal.pone.0250818. eCollection 2021.
5
KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα.KDM3B通过限制染色质可及性并促进全反式维甲酸（ATRA）介导的早幼粒细胞白血病/维甲酸受体α（PML/RARα）降解来抑制急性早幼粒细胞白血病（APL）进展。
Cancer Cell Int. 2019 Oct 4;19:256. doi: 10.1186/s12935-019-0979-7. eCollection 2019.
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