Alonso S J, Castellano M A, Afonso D, Rodriguez M
Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Physiol Behav. 1991 Jan;49(1):69-72. doi: 10.1016/0031-9384(91)90232-d.
Many studies have reported sex differences in the rates of depression in humans. Due to experimental problems, the nature of these sexual differences is still unknown. In the present study, we quantify the sex differences in depression using two animal models. Both the Porsolt et al. test and the Hilakivi and Hilakivi forced swimming test have shown that the duration of immobility is higher in the male than in the female. Sexual differences in the animal models of depression are probably unrelated to general activity differences because there is no significant correlation between activity in both tests. However, the correlation between the two models of depression used reached statistical significance. Finally, the immobility levels in the Porsolt test were similar in the different stages of the estrous cycle.
许多研究报告了人类抑郁症发病率的性别差异。由于实验问题，这些性别差异的本质仍然未知。在本研究中，我们使用两种动物模型量化了抑郁症中的性别差异。Porsolt等人的测试以及Hilakivi和Hilakivi的强迫游泳测试均表明，雄性的不动时间比雌性更长。抑郁症动物模型中的性别差异可能与一般活动差异无关，因为两项测试中的活动之间没有显著相关性。然而，所使用的两种抑郁症模型之间的相关性达到了统计学显著性。最后，在发情周期的不同阶段，Porsolt测试中的不动水平相似。
