Nishimura H, Tsuda A, Oguchi M, Ida Y, Tanaka M
Department of Pharmacology, Kurume University School of Medicine, Japan.
Physiol Behav. 1988;42(1):93-5. doi: 10.1016/0031-9384(88)90266-1.
Rats were forced to swim in a cistern until sinking in order to examine the possible relationship between sinking and immobility which has been reported to reflect "behavioral despair" in the forced swim test. Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test. The sinking rats showed significantly shorter immobility times during the first 15 min as compared to the non-sinking rats. Therefore, sinking behavior seems to be a sign of emotional behavior such as fear and/or anxiety accompanied by defecation. Discriminant analysis showed that the immobility time during the first 15 min was a prediction of sinking. These findings suggest that the rapidly induced immobility in this forced swim test reflects the possibility of floating behavior in connection with the emotional reaction.
为了研究下沉与不动之间可能存在的关系，将大鼠置于水箱中强迫其游泳直至下沉，据报道，在强迫游泳试验中，不动反映了“行为绝望”。根据2小时试验过程中下沉行为的表现，将大鼠分为下沉组和非下沉组。与非下沉组大鼠相比，下沉组大鼠在最初15分钟内的不动时间明显更短。因此，下沉行为似乎是一种伴有排便的恐惧和/或焦虑等情绪行为的表现。判别分析表明，最初15分钟内的不动时间可预测下沉情况。这些发现表明，在该强迫游泳试验中迅速诱发的不动反映了与情绪反应相关的漂浮行为的可能性。
