Inserm, U674, Génomique Fonctionnelle des Tumeurs Solides, Paris, France.
Semin Liver Dis. 2010 Feb;30(1):75-86. doi: 10.1055/s-0030-1247134. Epub 2010 Feb 19.
Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma (HCC) is challenging, both because of the tumor complexity and the difficulty in integrating the very large amount of data provided by different approaches. The authors consider it very important to identify new pathways of carcinogenesis and to understand the mechanisms underlying their alteration in tumors to design personalized treatments for HCC. In this review, the main global genomic approaches are considered in detail. The authors present a catalog of the most important oncogenes and tumor suppressor genes that have been found to be mutated in HCC and hepatocellular adenoma. They also review the results provided by transcriptome and miRNA profiling, in terms of molecular tumor classification. The authors anticipate that high-throughput sequencing will considerably refine the description of the genetic alterations in HCC. They also predict that systems biology, the recently developed interdisciplinary research field, will be very important to integrate the colossal amounts of data generated by the new technologies and to identify useful clinical applications.
鉴定肝癌 (HCC) 中的新癌基因和抑癌基因具有挑战性，这既是因为肿瘤的复杂性，也是因为整合不同方法提供的大量数据非常困难。作者认为，确定新的致癌途径并了解其在肿瘤中改变的机制以设计 HCC 的个性化治疗方案非常重要。在这篇综述中，详细考虑了主要的全基因组方法。作者列出了在 HCC 和肝细胞腺瘤中发现突变的最重要的癌基因和抑癌基因目录。他们还回顾了转录组和 miRNA 分析在分子肿瘤分类方面提供的结果。作者预计高通量测序将极大地完善 HCC 中遗传改变的描述。他们还预测，系统生物学作为最近发展起来的跨学科研究领域，对于整合新技术产生的海量数据以及识别有用的临床应用将非常重要。
