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腹腔镜辅助与开腹回肠结肠切除术治疗克罗恩病的长期结果。

Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's disease.

机构信息

Departments of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.

出版信息

Br J Surg. 2010 Apr;97(4):563-8. doi: 10.1002/bjs.6918.

Abstract

BACKGROUND

Long-term results of laparoscopically assisted versus open ileocolic resection for Crohn's disease were evaluated in a randomized trial.

METHODS

Sixty patients who underwent ileocolic resection between 1999 and 2003 were followed prospectively. Primary outcomes were reoperation, readmission and repeat resection rates for recurrent Crohn's disease. Secondary outcomes were quality of life (QOL), body image and cosmesis.

RESULTS

Five patients were lost to follow-up. Median follow-up was 6.7 (interquartile range 5.7-7.9) years. Sixteen of 29 and 16 of 26 patients remained relapse free after ileocolic resection in the laparoscopic and open groups respectively (risk difference 6 (95 per cent confidence interval - 20 to 32) per cent). Resection of recurrent Crohn's disease was necessary in two of 29 versus three of 26 patients (risk difference 5 (-11 to 20) per cent). Overall reoperation rates for recurrent Crohn's disease, incisional hernia and adhesion-related problems were two of 29 versus six of 26 (risk difference 16 (-3 to 35) per cent). QOL was similar, whereas body image and cosmesis scores were significantly higher after laparoscopy (P = 0.029 and P < 0.001 respectively).

CONCLUSION

Laparoscopically assisted ileocolic resection results in better body image and cosmesis, whereas open surgery is more likely to produce incisional hernia and obstruction.

摘要

背景

腹腔镜辅助与开腹回肠结肠切除术治疗克罗恩病的长期结果在一项随机试验中进行了评估。

方法

1999 年至 2003 年间,对 60 例行回肠结肠切除术的患者进行了前瞻性随访。主要结局是复发性克罗恩病的再手术、再入院和再次切除率。次要结局是生活质量(QOL)、身体形象和美容效果。

结果

5 例患者失访。中位随访时间为 6.7(四分位间距 5.7-7.9)年。腹腔镜组和开腹组分别有 16/29 和 16/26 例患者在回肠结肠切除术后无复发病例(风险差异 6(95%置信区间-20 至 32)%)。在腹腔镜组和开腹组,分别有 2/29 和 3/26 例患者需要切除复发性克罗恩病(风险差异 5(-11 至 20)%)。复发性克罗恩病、切口疝和粘连相关问题的总体再手术率为腹腔镜组 2/29 例,开腹组 6/26 例(风险差异 16(3 至 35)%)。QOL 相似,但腹腔镜组的身体形象和美容效果评分明显更高(P = 0.029 和 P < 0.001)。

结论

腹腔镜辅助回肠结肠切除术可获得更好的身体形象和美容效果,而开腹手术更易发生切口疝和梗阻。

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