University Hospital Freiburg, Eye Hospital, Freiburg, Germany.
Retina. 2010 Feb;30(2):332-8. doi: 10.1097/iae.0b013e3181baf691.
To report clinical and epidemiologic findings of 11 patients with severe intraocular inflammation after intravitreal injection.
This is a single-center, retrospective, interventional case series of 11 patients with severe intraocular inflammation after intravitreal injection at 1 referral center. The clinical data of all patients (3,357) who underwent intravitreal injection between February 2007 and February 2008 were analyzed. All incidents of postoperative intraocular inflammatory reaction were documented.
During the examination period, we identified 11 cases of intraocular inflammation after intravitreal injection. Only one thereof was infectious endophthalmitis with retinal abscess. All others were toxic vitreitis. Seven eyes exhibited hypopyon and five disseminated retinal hemorrhages. The toxic reaction occurred within 48 hours after injection, whereas in the endophthalmitis case, it occurred after 72 hours. We believe that the cause of this reaction was the particular syringe brand used. After changing to another syringe brand, no further cases of toxic vitreitis occurred during the next 6 months.
Toxic inflammatory reaction is not only a complication of cataract surgery, but may also occur after intravitreal injection. A critical review of all processes involved and materials used would help to prevent further cases of toxic vitreitis.
报告 11 例玻璃体内注射后严重眼内炎症的临床和流行病学发现。
这是一家转诊中心的 11 例玻璃体内注射后严重眼内炎症的单中心、回顾性、干预性病例系列研究。分析了 2007 年 2 月至 2008 年 2 月期间所有接受玻璃体内注射的 3357 例患者的临床资料。所有术后眼内炎症反应的事件均有记录。
在检查期间，我们发现了 11 例玻璃体内注射后的眼内炎症。只有 1 例是视网膜脓肿感染性眼内炎，其余均为中毒性玻璃体炎。7 只眼有前房积脓，5 只眼有弥漫性视网膜出血。中毒反应发生在注射后 48 小时内，而眼内炎病例则发生在 72 小时后。我们认为这种反应的原因是使用了特定的注射器品牌。更换另一种注射器品牌后，在接下来的 6 个月内，没有再发生中毒性玻璃体炎。
毒性炎症反应不仅是白内障手术的并发症，也可能发生在玻璃体内注射后。对所有涉及的过程和使用的材料进行严格审查有助于防止进一步发生毒性玻璃体炎。
