Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, WA 98195-7266, USA.
Sleep. 2010 Feb;33(2):252-9. doi: 10.1093/sleep/33.2.252.
To compare daytime sleepiness and neurobehavioral performance in children with active and inactive juvenile idiopathic arthritis (JIA), and explore relations among measures of sleep disturbance, daytime sleepiness, and neurobehavioral performance.
Cross-sectional, comparison.
A university-based research sleep laboratory.
Seventy (70) children 6-11 years of age with active or inactive JIA.
Self-reported daytime sleepiness, multiple sleep latency tests (MSLTs), and computerized neurobehavioral performance test scores were obtained after 2 nights of polysomnography. Children with active disease (mean physician global rating score = 2.9 +/- 1.9 SD) showed shorter mean MSLT latency (15 +/- 6.0 min) than those with inactive disease (16.5 +/- 5.5 min, P < 0.03). Scores on neurobehavioral performance tests showed no group differences. However, number of wake bouts predicted sustained visual attention (rapid visual processing, P < 0.05) and apnea hypopnea index (AHI) predicted reaction time (P < 0.0001), after controlling for age, IQ, medication, and disease status.
Indices of sleep disturbance were associated with validated tests of neurobehavioral performance in JIA, regardless of disease activity. Additional research is needed about the extent of sleep disturbances in relation to neurocognitive performance in JIA and compared to healthy children.
比较活动期和非活动期幼年特发性关节炎（JIA）患儿日间嗜睡和神经行为表现，并探讨睡眠障碍、日间嗜睡和神经行为表现之间的关系。
横断面比较。
大学基础研究睡眠实验室。
70 名 6-11 岁的活动期或非活动期 JIA 患儿。
在 2 晚多导睡眠图检查后，获得了自我报告的日间嗜睡、多次睡眠潜伏期试验（MSLT）和计算机神经行为表现测试评分。活动期疾病患儿（平均医生总体评分=2.9+/-1.9 SD）的平均 MSLT 潜伏期较短（15+/-6.0 分钟），而非活动期疾病患儿的平均 MSLT 潜伏期较长（16.5+/-5.5 分钟，P<0.03）。神经行为表现测试的评分无组间差异。然而，觉醒次数可预测持续视觉注意力（快速视觉处理，P<0.05），呼吸暂停低通气指数（AHI）可预测反应时间（P<0.0001），控制年龄、智商、药物和疾病状态后。
无论疾病活动度如何，睡眠障碍指标均与 JIA 的神经行为表现的验证性测试相关。需要进一步研究 JIA 患者与健康儿童相比，睡眠障碍与神经认知表现的程度。
