粒径、磁场和血流速度对磁靶向药物输送中粒子滞留的影响。
Particle size, magnetic field, and blood velocity effects on particle retention in magnetic drug targeting.
机构信息
Department of Mechanical Engineering, Stanford University, Stanford, California 94305, USA.
出版信息
Med Phys. 2010 Jan;37(1):175-82. doi: 10.1118/1.3271344.
PURPOSE
A physics-based model of a general magnetic drug targeting (MDT) system was developed with the goal of realizing the practical limitations of MDT when electromagnets are the source of the magnetic field.
METHODS
The simulation tracks magnetic particles subject to gravity, drag force, magnetic force, and hydrodynamic lift in specified flow fields and external magnetic field distributions. A model problem was analyzed to determine the effect of drug particle size, blood flow velocity, and magnetic field gradient strength on efficiency in holding particles stationary in a laminar Poiseuille flow modeling blood flow in a medium-sized artery.
RESULTS
It was found that particle retention rate increased with increasing particle diameter and magnetic field gradient strength and decreased with increasing bulk flow velocity.
CONCLUSIONS
The results suggest that MDT systems with electromagnets are unsuitable for use in small arteries because it is difficult to control particles smaller than about 20 microm in diameter.
目的
开发了一种基于物理的通用磁药物靶向（MDT）系统模型，旨在实现当电磁铁为磁场源时MDT 的实际限制。
方法
该模拟跟踪在指定流场和外部磁场分布中受重力、阻力、磁力和水动力升力影响的磁性颗粒。分析了一个模型问题，以确定药物颗粒大小、血流速度和磁场梯度强度对在模拟中保持中等大小动脉中血流的层流泊肃叶流动中颗粒静止的效率的影响。
结果
发现颗粒保留率随颗粒直径和磁场梯度强度的增加而增加，随主体流速的增加而减小。
结论
结果表明，使用电磁铁的 MDT 系统不适合用于小动脉，因为难以控制直径小于约 20 微米的颗粒。
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