Etlik Zübeyde Hanim Womens' Health Teaching and Research Hospital, Department of Obstetrics and Gynecology, Infertility Unit, Ankara, Turkey.
Gynecol Endocrinol. 2010 Jun;26(6):429-34. doi: 10.3109/09513591003632175.
To compare the efficacy of lyophilised urinary hMG (HP-hMG) with recombinant FSH (rFSH) in women with unexplained infertility undergoing a controlled ovarian hyperstimulation with intrauterine insemination (IUI).
Forty-nine consecutively seen women with unexplained infertility were randomised to a controlled ovarian hyperstimulation with IUI cycle either with rFSH or HP-hMG. The outcome was compared by independent samples t-test.
The mean patient age and duration of infertility were not different (29.5 +/- 5.7 and 4.9 +/- 2.7 years in rFSH; 28.8 +/- 3.2 and 6 +/- 4.2 in HP-hMG group) (p = 0.6 and p = 0.2). The mean body mass index (BMI) and basal hormones were similar. Total dose of gonadotropin used (710 +/- 236 vs. 636 +/- 185 IU) and duration of the cycles (9 +/- 2.1 vs. 8.3 +/- 2.3 days) showed no significant difference (p = 0.2). Number of follicles, serum oestradiol (E2), and the endometrial thickness on the day of hCG were comparable. Two singletons in each group were obtained.
These data suggest that HP-hMG and rFSH may be equally suitable in mild ovarian stimulation for unexplained infertility. Further data derived from larger study population are needed to determine whether higher amounts of two gonadotropins in this subgroup might produce any benefits or unfavourable effects.
比较冻干尿促性素（HP-hMG）与重组卵泡刺激素（rFSH）在不明原因不孕行控制性卵巢超排卵加宫腔内人工授精（IUI）治疗中的疗效。
49 例连续就诊的不明原因不孕患者随机分为 rFSH 组或 HP-hMG 组行控制性卵巢超排卵加 IUI 周期治疗。采用独立样本 t 检验比较两组的结果。
患者年龄和不孕时间的均值无差异（rFSH 组分别为 29.5±5.7 岁和 4.9±2.7 年；HP-hMG 组分别为 28.8±3.2 岁和 6±4.2 年）（p=0.6 和 p=0.2）。体重指数（BMI）和基础激素的均值相似。所用促性腺激素的总剂量（710±236IU 比 636±185IU）和周期持续时间（9±2.1 天比 8.3±2.3 天）无显著差异（p=0.2）。卵泡数、血清雌二醇（E2）和 hCG 日的子宫内膜厚度无差异。每组各有 2 例单胎妊娠。
这些数据提示，HP-hMG 和 rFSH 可能同样适用于不明原因不孕的轻度卵巢刺激。需要更大的研究人群数据来确定这一亚组中两种促性腺激素的用量增加是否会产生任何益处或不利影响。
