Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Acta Neurol Scand. 2010 Dec;122(6):377-82. doi: 10.1111/j.1600-0404.2010.01327.x.
To assess the association between active and passive smoking and the risk of Parkinson's disease (PD), a case-control study with 249 PD patients and 369 controls was carried out in Japan.
Information on smoking was obtained through a self-administered questionnaire. Adjustment was made for age, sex, region of residence, educational level, and occupational exposure.
Ever having smoked cigarettes was associated with a reduced risk of PD [adjusted odds ratio = 0.38; 95% confidence interval (CI): 0.24-0.59]. Risk for former smokers was intermediate between the high risk for never smokers and the low risk for current smokers. Adjusted odds ratios for former and current smokers were 0.51 (95% CI: 0.32-0.82) and 0.12 (95% CI: 0.05-0.26), respectively. There was an inverse dose-response gradient with pack-years smoked. No significant association was detected for passive smoking exposure.
Our results appear to confirm data from previous epidemiological studies.
评估主动和被动吸烟与帕金森病（PD）风险之间的关联，在日本进行了一项包含 249 名 PD 患者和 369 名对照的病例对照研究。
通过自我管理问卷获取有关吸烟的信息。调整了年龄、性别、居住地区、教育程度和职业暴露因素。
曾经吸烟与 PD 的风险降低相关[调整后的优势比=0.38；95%置信区间（CI）：0.24-0.59]。与从不吸烟者的高风险相比，前吸烟者的风险处于中间水平，而与当前吸烟者的低风险相比。前吸烟者和现吸烟者的调整优势比分别为 0.51（95%CI：0.32-0.82）和 0.12（95%CI：0.05-0.26）。吸烟量与患病风险呈负相关。未发现被动吸烟暴露与 PD 风险之间存在显著关联。
我们的结果似乎证实了先前流行病学研究的数据。
