Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
J Neurol Sci. 2011 Jul 15;306(1-2):98-102. doi: 10.1016/j.jns.2011.03.035. Epub 2011 Apr 16.
Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10-0.57, P for trend=0.0003) for iron, 0.33 (95% CI: 0.13-0.81, P for trend=0.007) for magnesium and 0.50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD.
金属在神经系统的几个重要功能中发挥作用。在帕金森病（PD）中，黑质中的锌和铁增加，铜减少。然而，关于饮食中金属摄入与 PD 风险之间的关联的流行病学证据有限。我们使用来自多中心基于医院的病例对照研究的数据，在日本研究了金属消耗与 PD 风险之间的关系。包括根据英国 PD 协会脑库临床诊断标准在发病后 6 年内的 249 例病例。对照组为无神经退行性疾病的 368 名住院患者和门诊患者。使用自我管理的饮食史问卷收集了有关饮食因素的信息。铁、镁和锌的摄入量较高与 PD 风险降低独立相关：最高四分位组的调整 OR 为 0.24（95%CI：0.10-0.57，趋势 P=0.0003），铁为 0.33（95%CI：0.13-0.81，趋势 P=0.007），镁为 0.50（95%CI：0.26-0.95，趋势 P=0.055）。铜或锰的摄入量与 PD 风险之间没有关系。铁、镁和锌的摄入量较高可能对 PD 有保护作用。
