左旋多巴能否改善帕金森病患者的吞咽功能障碍？
Does levodopa improve swallowing dysfunction in Parkinson's disease patients?
机构信息
Federal University of Bahia, Bahia, Brazil.
出版信息
J Clin Pharm Ther. 2009 Dec;34(6):673-6. doi: 10.1111/j.1365-2710.2009.01031.x.
OBJECTIVE
To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients.
METHODS
A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +/- standard deviation were considered for analysis. The primary efficacy variables were Oral Transit Time (OTT), Pharyngeal Transit Time (PTT) for both thin fluids and solids, and aspiration.
RESULTS
Seven studies describing swallowing functions in PD patients using levodopa were found, and five of these matched the inclusion criteria. No clinically meaningful improvement after levodopa intake was noted. Adverse effects were not reported by the authors.
CONCLUSION
This meta-analysis shows that levodopa intake was not associated with an improvement of swallowing dysfunction in Parkinson's disease patients.
目的
评估左旋多巴对帕金森病患者吞咽功能障碍的影响。
方法
进行了系统的文献回顾和荟萃分析。所有涉及左旋多巴和吞咽功能障碍的研究，只要提供了直接数据或可以转化为平均值±标准差的数据，都被认为是有分析价值的。主要的疗效变量是口腔通过时间（OTT）、稀薄液体和固体的咽通过时间（PTT）以及吸入。
结果
共发现 7 项研究描述了使用左旋多巴的 PD 患者的吞咽功能，其中 5 项符合纳入标准。在摄入左旋多巴后没有观察到有临床意义的改善。作者没有报告不良反应。
结论
这项荟萃分析表明，帕金森病患者摄入左旋多巴与吞咽功能障碍的改善无关。
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