Harms Paul W, Bandarchi Bizhan, Ma Linglei
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109-0602, USA.
J Cutan Pathol. 2010 Sep;37(9):953-7. doi: 10.1111/j.1600-0560.2010.01533.x. Epub 2010 Feb 18.
Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable. CD163 is highly specific for normal and neoplastic cells of the monocyte/histiocyte lineage. In this study, we examined the value of CD163 in the diagnosis of acute myeloid LC.
A total of 34 cases, including 18 cases of myelomonocytic or monocytic LC, 10 cases of myeloid LC without monocytic component and 6 cases of acute lymphoblastic leukemia/lymphoma (ALL), were stained with CD163.
CD163 was expressed in 8 of 18 (44%) of myelomonocytic or monocytic LC and 1 of 10 (10%) of other myeloid LC, but in none of the ALL cases (0/6). CD163 was highly specific (90%) for myeloid LC with a monocytic component, but showed low sensitivity in the diagnosis of both myeloid LC in general (24%) and myeloid LC with a monocytic component (44%).
Our results suggest that CD163 has utility as a specific marker for myeloid LC in conjunction with currently used immunohistochemical stains, but should not be used alone for diagnosis.
正确诊断皮肤型髓系白血病（LC）具有重要的临床意义，但可能存在困难，因为没有单一的免疫组化标志物对明确诊断具有足够的敏感性或特异性。因此，通常需要更广泛的标志物组合。CD163对单核细胞/组织细胞谱系的正常和肿瘤细胞具有高度特异性。在本研究中，我们检测了CD163在急性髓系皮肤型白血病诊断中的价值。
对34例病例进行CD163染色，其中包括18例粒单核细胞或单核细胞皮肤型白血病、10例无单核细胞成分的髓系皮肤型白血病和6例急性淋巴细胞白血病/淋巴瘤（ALL）。
在18例粒单核细胞或单核细胞皮肤型白血病中有8例（44%）表达CD163，在10例其他髓系皮肤型白血病中有1例（10%）表达CD163，但在所有急性淋巴细胞白血病/淋巴瘤病例中均未表达（0/6）。CD163对有单核细胞成分的髓系皮肤型白血病具有高度特异性（90%），但在总体髓系皮肤型白血病诊断中敏感性较低（24%），在有单核细胞成分的髓系皮肤型白血病诊断中敏感性也较低（44%）。
我们的结果表明，CD163作为髓系皮肤型白血病的特异性标志物，与目前使用的免疫组化染色联合应用具有一定作用，但不应单独用于诊断。
