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皮肤血管病伴广泛真皮毛细血管血栓形成 1 例。

Case of livedoid vasculopathy with extensive dermal capillary thrombi.

机构信息

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

出版信息

J Dermatol. 2010 Jan;37(1):94-7. doi: 10.1111/j.1346-8138.2009.00753.x.

Abstract

Livedoid vasculopathy (LV) is thought to be a thrombogenic disorder. Here, we report a case of LV presenting livedo reticularis with leg ulcers clinically and many thrombogenic cutaneous vessels histologically. These features strongly suggested the presence of thrombogenic factors involved with the development of the lesions. After examination of various possible thrombogenic factors including phosphatidylserine-dependent anti-prothrombin antibody, we failed to detect any responsible thrombogenic factors for this case of LV. Recently, diverse thrombogenic factors have been reported to be involved in LV. This case may suggest that unknown thrombogenic factors are additionally related to LV pathogenesis.

摘要

获得性皮肤白细胞破碎性血管炎(LV)被认为是一种血栓形成性疾病。在此,我们报告一例临床上表现为网状青斑伴腿部溃疡,组织学上表现为大量血栓形成性皮肤血管的 LV 病例。这些特征强烈提示存在与病变发展相关的血栓形成性因素。在检查了包括依赖磷脂酰丝氨酸的抗凝血酶原抗体在内的各种可能的血栓形成性因素后,我们未能发现该例 LV 的任何负责的血栓形成性因素。最近,有报道称多种血栓形成性因素与 LV 有关。该病例可能提示,未知的血栓形成性因素也与 LV 的发病机制有关。

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