Dermatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.
Autoimmun Rev. 2011 Apr;10(6):353-60. doi: 10.1016/j.autrev.2010.11.008. Epub 2010 Dec 22.
Livedoid vasculopathy is an occlusive cutaneous disease of the dermal vessels with pauci-inflammatory or non-inflammatory histopathology findings. It is characterized by the presence of macules or papules, erythemato-purpuric lesions located on the legs, especially on the ankles and feet, which produce ulcerations that are intensely painful and originate ivory atrophic scars called "atrophie blanche". In this review article, studies on LV from the literature are analyzed, and their etiopathogenic associations, particularly those related to the thrombophilic states, as well as the pathologic findings and therapeutic approaches applied in the difficult clinical management of these cases, are evaluated.
皮肤白细胞碎裂性血管病是一种以皮肤小血管闭塞为特征的皮肤疾病，其组织病理学表现为少炎或非炎。该病的特征是存在红斑或丘疹、位于腿部（尤其是踝关节和足部）的红斑性紫癜性皮损，这些皮损会导致溃疡，且溃疡疼痛剧烈，并产生称为“白萎缩”的象牙色萎缩性瘢痕。在这篇综述文章中，对文献中关于 LV 的研究进行了分析，并评估了其发病机制的关联，特别是与血栓形成状态相关的关联，以及在这些病例的困难临床管理中应用的病理发现和治疗方法。
