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[萎缩性硬化性苔藓样皮炎。皮肤梗死的发病机制、诊断与治疗]

[Livedoid vasculopathy. Pathogenesis, diagnosis and treatment of cutaneous infarction].

作者信息

Goerge T

机构信息

Hautklinik, Universitätsklinikum Münster.

出版信息

Hautarzt. 2011 Aug;62(8):627-34; quiz 635. doi: 10.1007/s00105-011-2172-3.

DOI:10.1007/s00105-011-2172-3
PMID:21786003
Abstract

Livedo vasculopathy is a chronic recurrent disease of the cutaneous circulation and is characterized by episodic occurrence of painful ulcerations of the lower leg. These heal slowly leaving small porcelain-white scars called atrophie blanche. Recent research has shown that livedoid vasculopathy is a coagulation disorder classified as a vasculopathy different from inflammatory vasculitis. Distinguishing between the disorders enhances the pathophysiologic understanding and supports the therapeutic rationale. The prevention of irreversible residual scarring is the main goal in treating cutaneous infarction; prompt treatment is required.

摘要

青斑样血管病是一种皮肤循环的慢性复发性疾病,其特征是小腿反复出现疼痛性溃疡。这些溃疡愈合缓慢,会留下称为白色萎缩的小瓷白色疤痕。最近的研究表明,类脂质渐进性坏死性皮病是一种凝血障碍,被归类为不同于炎症性血管炎的血管病。区分这些疾病有助于增强对病理生理学的理解,并支持治疗原理。预防不可逆的残留疤痕是治疗皮肤梗死的主要目标;需要及时治疗。

相似文献

1
[Livedoid vasculopathy. Pathogenesis, diagnosis and treatment of cutaneous infarction].[萎缩性硬化性苔藓样皮炎。皮肤梗死的发病机制、诊断与治疗]
Hautarzt. 2011 Aug;62(8):627-34; quiz 635. doi: 10.1007/s00105-011-2172-3.
2
Livedoid vasculopathy - current aspects of diagnosis and treatment of cutaneous infarction.皮肤梗死的 livedoid 血管病变 - 目前的诊断和治疗方面。
J Dtsch Dermatol Ges. 2013 May;11(5):407-10. doi: 10.1111/ddg.12064. Epub 2013 Feb 26.
3
Livedoid vasculopathy - a thrombotic disease.萎缩性硬化性苔藓样血管病——一种血栓性疾病。
Vasa. 2013 Sep;42(5):317-22. doi: 10.1024/0301-1526/a000296.
4
Livedoid vasculopathy: an intringuing cutaneous disease.萎缩性硬化性苔藓样皮炎:一种引人关注的皮肤疾病。
An Bras Dermatol. 2011 Sep-Oct;86(5):961-77. doi: 10.1590/s0365-05962011000500015.
5
Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders.与皮肤婴儿血管瘤 involutional 期相关的单侧类紫癜性血管病:与凝血障碍的关联
Int J Low Extrem Wounds. 2013 Dec;12(4):306-9. doi: 10.1177/1534734613502049. Epub 2013 Sep 16.
6
Atrophie blanche: is it associated with venous disease or livedoid vasculopathy?白色萎缩:它与静脉疾病或类脂质渐进性坏死性血管病有关吗?
Adv Skin Wound Care. 2014 Nov;27(11):518-24; quiz 525-6. doi: 10.1097/01.ASW.0000455098.98684.95.
7
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease.镰状细胞病患者出现的萎缩性血管病变
Am J Dermatopathol. 2018 Sep;40(9):682-685. doi: 10.1097/DAD.0000000000001133.
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Negative Results, Positive Outcome: A Case of Primary Livedoid Vasculopathy With an Elusive Laboratory Workup.阴性结果,阳性结局:原发性皮肤白细胞碎裂性血管病的一例,实验室检查结果难以捉摸。
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241266090. doi: 10.1177/23247096241266090.
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Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin.成功用小剂量华法林治疗类脂蛋白血管病伴发周围神经病 1 例
J Dermatol. 2010 Jan;37(1):98-101. doi: 10.1111/j.1346-8138.2009.00754.x.
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Livedoid vasculopathy as a coagulation disorder.皮肤白细胞碎裂性血管病作为一种凝血障碍。
Autoimmun Rev. 2011 Apr;10(6):353-60. doi: 10.1016/j.autrev.2010.11.008. Epub 2010 Dec 22.

引用本文的文献

1
The Histopathology of Leg Ulcers.腿部溃疡的组织病理学
Dermatopathology (Basel). 2024 Jan 29;11(1):62-78. doi: 10.3390/dermatopathology11010007.
2
Clinical, Laboratory, Histopathological and Therapeutic Profile of Livedoid Vasculopathy: A Case Series of 17 Patients.类脂质渐进性坏死性血管病的临床、实验室、组织病理学及治疗概况:17例病例系列研究
Indian Dermatol Online J. 2022 Oct 21;13(6):771-774. doi: 10.4103/idoj.idoj_182_22. eCollection 2022 Nov-Dec.
3
Livedoid vasculopathy - A diagnostic and therapeutic challenge.萎缩性硬化性苔藓样血管病——诊断与治疗的挑战。

本文引用的文献

1
Livedoid vasculopathy in a pediatric patient with elevated lipoprotein(a) levels: prompt response to continuous low-molecular-weight heparin.脂蛋白(a)水平升高的儿科患者的类脂质渐进性坏死性血管病:对持续低分子量肝素的迅速反应
Arch Dermatol. 2010 Aug;146(8):927-8. doi: 10.1001/archdermatol.2010.177.
2
[Dermatologic aspects of anticoagulation].[抗凝治疗的皮肤学问题]
Hautarzt. 2010 Aug;61(8):705-16; quiz 717-8. doi: 10.1007/s00105-010-1996-6.
3
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.
Front Med (Lausanne). 2022 Oct 3;9:1012178. doi: 10.3389/fmed.2022.1012178. eCollection 2022.
4
A Phase II Multicenter Trial With Rivaroxaban in the Treatment of Livedoid Vasculopathy Assessing Pain on a Visual Analog Scale.一项关于利伐沙班治疗类癌性血管病的II期多中心试验:基于视觉模拟评分法评估疼痛
JMIR Res Protoc. 2014 Dec 10;3(4):e73. doi: 10.2196/resprot.3640.
5
[Leg discoloration].[腿部变色]
Internist (Berl). 2013 Nov;54(11):1314-22. doi: 10.1007/s00108-013-3341-5.
脂蛋白(a)浓度与冠心病、中风及非血管性死亡风险
JAMA. 2009 Jul 22;302(4):412-23. doi: 10.1001/jama.2009.1063.
4
[Therapy of vasculitides and vasculopathies].[血管炎和血管病的治疗]
Hautarzt. 2008 May;59(5):382-93. doi: 10.1007/s00105-008-1530-2.
5
Long-term safety and efficacy data on childhood venous thrombosis treated with a low molecular weight heparin: an open-label pilot study of once-daily versus twice-daily enoxaparin administration.低分子量肝素治疗儿童静脉血栓形成的长期安全性和疗效数据:一项关于每日一次与每日两次依诺肝素给药的开放标签试点研究。
Haematologica. 2006 Dec;91(12):1701-4.
6
Livedoid vasculopathy: what it is and how the patient should be evaluated and treated.萎缩性硬化性苔藓样血管炎:其本质以及患者应如何进行评估和治疗。
Arch Dermatol. 2006 Nov;142(11):1481-2. doi: 10.1001/archderm.142.11.1481.
7
Livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity (4G/4G) treated successfully with tissue plasminogen activator.与纤溶酶原激活物抑制剂-1启动子纯合子(4G/4G)相关的萎缩性血管病经组织纤溶酶原激活物成功治疗。
Arch Dermatol. 2006 Nov;142(11):1466-9. doi: 10.1001/archderm.142.11.1466.
8
Livedoid vasculopathy. The role of hyperhomocysteinemia and its simple therapeutic consequences.萎缩性硬化性苔藓样血管病。高同型半胱氨酸血症的作用及其简单的治疗效果。
Eur J Dermatol. 2006 Mar-Apr;16(2):159-62.
9
Warfarin therapy for livedoid vasculopathy associated with cryofibrinogenemia and hyperhomocysteinemia.华法林治疗与冷纤维蛋白原血症和高同型半胱氨酸血症相关的类癌性血管病。
Arch Dermatol. 2006 Jan;142(1):75-8. doi: 10.1001/archderm.142.1.75.
10
Pulsed intravenous immunoglobulin therapy in livedoid vasculitis: an open trial evaluating 9 consecutive patients.脉冲式静脉注射免疫球蛋白治疗类脂质渐进性坏死性血管炎:一项评估9例连续患者的开放性试验。
J Am Acad Dermatol. 2004 Oct;51(4):574-9. doi: 10.1016/j.jaad.2004.05.003.