Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
Int J Gynaecol Obstet. 2010 Jun;109(3):235-8. doi: 10.1016/j.ijgo.2010.01.007. Epub 2010 Feb 21.
To evaluate the prevalence of the different human papillomavirus (HPV) genotypes in women seen at 2 Marmara University Hospital gynecologic outpatient clinics in Istanbul, Turkey.
From May 1 through August 31, 2008, specimens were obtained from 500 women for cytologic evaluation by the split-sample method. HPV types were identified by PCR and hybridization using a microarray that identifies 35 types.
The overall prevalence of HPV was 16.5%, multiple genotypes were found in 35.8% of the infected women, and 75% of the types were high risk; 79% of the infected women had negative cytologic results, 3.7% had ASCUS, 10% had LSIL, and 6% had HSIL; the highest infection rates were 36% for women aged 20 to 30 years and 35% for those aged 31 to 40 years; 65.2% of the infected women were university graduates; and 34% were single.
HPV infection involved numerous types, most of them high risk, even in women with negative cytology results. Further studies with larger groups will provide more information on HPV distribution in Turkey, which may guide the development of local vaccination programs.
评估在土耳其伊斯坦布尔的 2 家马尔马拉大学医院妇科门诊就诊的女性中不同人乳头瘤病毒（HPV）基因型的流行情况。
2008 年 5 月 1 日至 8 月 31 日，通过分样法从 500 名女性中获得标本进行细胞学评估。使用微阵列通过 PCR 和杂交鉴定 HPV 类型，该微阵列可识别 35 种类型。
HPV 的总体流行率为 16.5%，感染女性中有 35.8%存在多种基因型，且 75%为高危型；79%的感染女性细胞学结果为阴性，3.7%为 ASCUS，10%为 LSIL，6%为 HSIL；感染率最高的是 20 至 30 岁的女性，为 36%，其次是 31 至 40 岁的女性，为 35%；65.2%的感染女性为大学毕业生；34%为单身。
HPV 感染涉及多种类型，大多数为高危型，即使在细胞学结果为阴性的女性中也是如此。进一步的大规模研究将提供更多关于 HPV 在土耳其分布的信息，这可能有助于制定当地的疫苗接种计划。
