土耳其妇科门诊女性的人乳头瘤病毒（HPV）流行率和类型。
Human papillomavirus (HPV) prevalence and types among Turkish women at a gynecology outpatient unit.
机构信息
Baskent University School of Medicine, Department of Obstetrics & Gynecology, Ankara, Turkey.
出版信息
BMC Infect Dis. 2009 Nov 30;9:191. doi: 10.1186/1471-2334-9-191.
BACKGROUND
Human Papillomavirus (HPV) is a well-known pathogen for lower genital tract neoplasias, yet little is known regarding HPV prevalence in Turkey. The aim of this study was to investigate the prevalence of HPV DNA and to determine HPV types distribution among women with normal and abnormal cytology.
METHODS
A total of five hundred seven (n = 507) women were retrospectively evaluated between 2004-2008. Conventional polymerase chain reaction was used to detect the presence of HPV types in cervicovaginal samples obtained from patients during gynecologic examination.
RESULTS
One hundred four (n = 104) of the women were excluded from the study because of the incomplete data and a total of 403 women were used for the final analysis. There were, 93 (23%) women with cytologic abnormality and 310 (77%) women with normal cytology. Overall, 23% of the women was HPV positive. The overall prevalence of HPV in women with abnormal Pap smears was 36% (93/403), of which in ASCUS 22%, LSIL 51% and HSIL 60%. Also, HPV DNA was positive in 20% of the women with normal cervical cytology. The most common HPV types in cytologically normal women were as follows; HPV 16 (36%), HPV 6 (22%) and HPV 18 (13%). The rate of other HPV types were as follows; HPV11 4.4%, HPV45 4.4%, HPV90 4.4%, HPV35 2.2%, HPV67 2.2%, HPV81 2.2%, and multiple type HPVs 8.9%. The most common HPV types in cytologically abnormal women were HPV 16 (35%), HPV6 (19%) and HPV18 (8%). The rate of multiple HPV infections in women with normal Pap test was 2.2%.
CONCLUSION
HPV prevalence and type distribution in this study were similar to that reported worldwide at least in our study population. Hovewer, HPV prevalence was more common compared with previous studies reported from Turkey. This might be related with methodology and hospital based patient accrual and high rate of women with abnormal cytology. Further population based prospective studies are needed to eliminate the drawbacks of our study and to determine nonhospital based HPV prevalence in Turkish women.
背景
人乳头瘤病毒（HPV）是一种众所周知的下生殖道肿瘤病原体，但关于土耳其 HPV 流行率的信息知之甚少。本研究旨在调查 HPV DNA 的流行率，并确定正常和异常细胞学女性中 HPV 类型的分布。
方法
2004-2008 年间共回顾性评估了 507 名女性（n=507）。在妇科检查中从患者宫颈阴道样本中使用常规聚合酶链反应检测 HPV 类型的存在。
结果
由于数据不完整，104 名女性（n=104）被排除在研究之外，共有 403 名女性被纳入最终分析。93 名（23%）女性细胞学异常，310 名（77%）女性细胞学正常。总体而言，23%的女性 HPV 阳性。异常巴氏涂片女性 HPV 总阳性率为 36%（93/403），其中 ASCUS 为 22%，LSIL 为 51%，HSIL 为 60%。此外，正常宫颈细胞学的女性中 HPV DNA 阳性率为 20%。细胞学正常女性中最常见的 HPV 类型如下：HPV 16（36%）、HPV 6（22%）和 HPV 18（13%）。其他 HPV 类型的发生率如下：HPV11 4.4%、HPV45 4.4%、HPV90 4.4%、HPV35 2.2%、HPV67 2.2%、HPV81 2.2%和多种类型 HPV 8.9%。细胞学异常女性中最常见的 HPV 类型为 HPV 16（35%）、HPV6（19%）和 HPV18（8%）。正常巴氏涂片女性中 HPV 多重感染率为 2.2%。
结论
本研究中的 HPV 流行率和类型分布与全球至少在我们的研究人群中报道的相似。然而，与来自土耳其的先前报道相比，HPV 的流行率更高。这可能与方法学以及医院为基础的患者招募和高比例的细胞学异常女性有关。需要进一步进行基于人群的前瞻性研究，以消除本研究的缺陷，并确定土耳其女性中基于医院的 HPV 流行率。
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