Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aza Aoba, Sendai 980-8579, Japan.
J Biomech. 2010 May 7;43(7):1386-93. doi: 10.1016/j.jbiomech.2010.01.011. Epub 2010 Feb 21.
We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles. A two-dimensional spring network of membrane particles is employed for expressing the deformation of malaria infected red blood cells (IRBCs). Malaria parasite within the IRBC is modeled as a rigid object. This model is applied to the stretching of IRBCs by optical tweezers, the deformation of IRBCs in shear flow, and the occlusion of narrow channels by IRBCs. We also investigate the effects of IRBCs on the rheological property of blood in micro-channels. Our results indicate that apparent viscosity is drastically increased for the period from the ring stage and the trophozoite stage, whereas it is not altered in the early stage of infection.
我们提出了一个由疟疾感染引起的血液动力学数值模型。该模型基于粒子方法，其中所有血液成分都由有限数量的粒子表示。采用二维细胞膜粒子弹簧网络来表示疟原虫感染的红细胞（IRBC）的变形。IRBC 内的疟原虫被建模为刚性物体。该模型应用于光学镊子拉伸 IRBC、IRBC 在剪切流中的变形以及 IRBC 阻塞狭窄通道。我们还研究了 IRBC 对微通道中血液流变性质的影响。我们的结果表明，从环早期和滋养体早期开始，表观粘度急剧增加，而在感染的早期阶段没有改变。
