Yang Ying, Lu Xiang-Feng
Department of Population Genetics and Prevention, Fu Wai Hospital alt; Cardiovascular Institute, Peking Union Medical College alt; Chinese Academy of Medical Sciences, Beijing 100037, China.
Yi Chuan. 2010 Feb;32(2):97-104. doi: 10.3724/sp.j.1005.2010.00097.
As a new effective strategy for researching complex diseases, genome-wide association study (GWAS) has being developed rapidly in recent years worldwide. The world genomic study has been taken into a new stage, since a series of disease related genes or variants have been identified by GWAS strategy. Coronary heart disease (CHD) is a complex disease that is caused by both environmental and genetic factors, and has become one of the leading causes of death and disability worldwide. With the application of GWAS strategy, researchers from all over the world have identified many susceptibility loci or regions of CHD that were unable to be identified by candidate gene case-control study. The present paper reviewed the important progresses worldwide attained in GWAS of CHD in recent years. Then it is also expounded the challenges we are facing nowadays in GWAS as well as the future study direction. The information outlined in this paper provides us a valuable guidance upon further exploration into genetic mechanism of CHD.
作为一种研究复杂疾病的新型有效策略，全基因组关联研究（GWAS）近年来在全球范围内迅速发展。自从通过GWAS策略鉴定出一系列与疾病相关的基因或变异以来，全球基因组研究已进入一个新阶段。冠心病（CHD）是一种由环境和遗传因素共同导致的复杂疾病，已成为全球死亡和残疾的主要原因之一。随着GWAS策略的应用，世界各地的研究人员已经鉴定出许多冠心病的易感基因座或区域，而这些是候选基因病例对照研究无法鉴定出来的。本文综述了近年来全球在冠心病GWAS方面取得的重要进展。同时也阐述了我们目前在GWAS中面临的挑战以及未来的研究方向。本文概述的信息为我们进一步探索冠心病的遗传机制提供了宝贵的指导。
