Li Yan-Yan, Zhou Chuan-Wei, Xu Jian, Qian Yun, Wang Xiang-Ming
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
Int J Clin Exp Med. 2015 Jun 15;8(6):8995-9003. eCollection 2015.
The interleukin-6 (IL-6) C-572G gene polymorphism has been suggested to be associated with the increased coronary artery disease (CAD) risk, but the study results are still debatable. To explore the association between IL-6 C-572G gene polymorphism and CAD in the Asian population, the current meta-analysis involving 2511 subjects from 7 separate studies was conducted. The combined odds ratio (ORs) for the association between IL-6 C-572G gene polymorphism and CAD and their corresponding 95% confidence intervals (95% CIs) were assessed by random or fixed effect model. A significant association between IL-6 C-572G gene polymorphism and CAD was found in the Asian population under an allelic (OR: 1.50, 95% CI: 1.30-1.71, P<0.00001), recessive (OR: 2.221, 95% CI: 1.444-3.417, P=1.0×10(-10)) dominant (OR: 1.313, 95% CI: 1.188-1.451, P=1.0×10(-10)), homozygous (OR: 2.454, 95% CI: 1.606-3.751, P=1.0×10(-10)), heterozygous (OR: 3.01, 95% CI:1.99-4.55, P<0.00001) and additive genetic models (OR: 1.372, 95% CI: 1.231-1.528, P=1.0×10(-10)). In the Asian population, the IL-6 C-572G gene polymorphism was indicated to be correlated with CAD susceptibility. The carriers of -572G allele might be predisposed to CAD risk.
白细胞介素-6（IL-6）C-572G基因多态性被认为与冠状动脉疾病（CAD）风险增加有关，但研究结果仍存在争议。为了探讨亚洲人群中IL-6 C-572G基因多态性与CAD之间的关联，进行了本次荟萃分析，纳入了来自7项独立研究的2511名受试者。通过随机或固定效应模型评估IL-6 C-572G基因多态性与CAD关联的合并比值比（OR）及其相应的95%置信区间（95%CI）。在亚洲人群中，发现IL-6 C-572G基因多态性与CAD之间存在显著关联，在等位基因（OR：1.50，95%CI：1.30 - 1.71，P<0.00001）、隐性（OR：2.221，95%CI：1.444 - 3.417，P = 1.0×10(-10)）、显性（OR：1.313，95%CI：1.188 - 1.451，P = 1.0×10(-10)）、纯合子（OR：2.454，95%CI：1.606 - 3.751，P = 1.0×10(-10)）、杂合子（OR：3.01，95%CI：1.99 - 4.55，P<0.00001）和加性遗传模型（OR：1.372，95%CI：1.231 - 1.528，P = 1.0×10(-10)）下均如此。在亚洲人群中，IL-6 C-572G基因多态性与CAD易感性相关。-572G等位基因的携带者可能易患CAD风险。
