荧光显微镜显示，替拉万星增强了对金黄色葡萄球菌分裂隔膜的靶向作用。
Fluorescence microscopy demonstrates enhanced targeting of telavancin to the division septum of Staphylococcus aureus.
机构信息
Theravance, Inc., Department of Molecular and Cellular Biology, South San Francisco, CA 94080, USA.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2198-200. doi: 10.1128/AAC.01609-09. Epub 2010 Feb 22.
Abstract
The cellular binding patterns of fluorescent conjugates of telavancin and vancomycin were evaluated in Staphylococcus aureus by fluorescence microscopy and ratio imaging analysis. Telavancin showed enhanced binding at the division septum compared to vancomycin. This result is consistent with observations that telavancin binds with higher affinity to lipid II than to d-Ala-d-Ala residues in the cell wall, thus demonstrating the preferential binding of telavancin to the site of active cell wall biosynthesis.
摘要
通过荧光显微镜和比率成像分析评估了替拉万星和万古霉素的荧光缀合物在金黄色葡萄球菌中的细胞结合模式。与万古霉素相比，替拉万星在分裂隔膜处的结合增强。这一结果与观察结果一致，即替拉万星与脂质 II 的结合亲和力高于细胞壁中的 d-Ala-d-Ala 残基，从而证明了替拉万星优先与活性细胞壁生物合成部位结合。
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