Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4705-9. doi: 10.1073/pnas.0910397107. Epub 2010 Feb 22.
General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or draws on specialized systems mediating their interactions. Here we investigated the neural substrates of g in 241 patients with focal brain damage using voxel-based lesion-symptom mapping. A hierarchical factor analysis across multiple cognitive tasks was used to derive a robust measure of g. Statistically significant associations were found between g and damage to a remarkably circumscribed albeit distributed network in frontal and parietal cortex, critically including white matter association tracts and frontopolar cortex. We suggest that general intelligence draws on connections between regions that integrate verbal, visuospatial, working memory, and executive processes.
一般智力（g）捕捉到跨认知任务共享的表现差异，并与现实世界的成功相关。然而，g 是否反映了参与这些任务的大脑系统的综合表现，还是依赖于专门的系统来调节它们的相互作用，这仍然存在争议。在这里，我们使用基于体素的病变-症状映射技术，在 241 名患有局灶性脑损伤的患者中研究了 g 的神经基础。通过对多个认知任务进行层次因素分析，得出了 g 的一个稳健衡量标准。在 g 与额叶和顶叶皮层中一个显著的但分布广泛的网络的损伤之间发现了统计学上显著的关联，该网络包括白质连接束和额极皮层。我们认为，一般智力依赖于整合言语、视空间、工作记忆和执行过程的区域之间的连接。
