Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstrasse 12, 24105 Kiel, Germany.
J Dent Res. 2010 Apr;89(4):384-8. doi: 10.1177/0022034509359575. Epub 2010 Feb 22.
COX-2 plays an important role in periodontitis by mediating inflammatory reactions in periodontal tissues, and the COX-2 polymorphisms rs20417 and rs689466 have been reported to be associated with periodontitis in populations of Taiwanese and Chinese ethnicity. To test whether these variants were associated with periodontitis in populations of European ethnicity, we genotyped the single-nucleotide polymorphisms (SNPs) rs689466 and rs6681231, the latter a haplotype tagging SNP (htSNP) for rs20417 (r2>0.95), in our large-analysis population of individuals with aggressive (n = 532) and chronic periodontitis (n = 1052), and 2873 healthy control individuals. The rare G allele of htSNP rs6681231 was associated with aggressive periodontitis prior to and after adjustment for the covariates smoking, diabetes, and gender, with an odds ratio of 1.57 (95% confidence interval 1.18-2.08; p = 0.002). The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis.
COX-2 通过介导牙周组织中的炎症反应，在牙周炎中发挥重要作用，已有报道 COX-2 多态性 rs20417 和 rs689466 与台湾和中国人群的牙周炎有关。为了检验这些变体是否与欧洲人群的牙周炎有关，我们对单核苷酸多态性（SNP）rs689466 和 rs6681231 进行了基因分型，后者是 rs20417 的单倍型标签 SNP（htSNP）（r2>0.95），我们对患有侵袭性（n=532）和慢性牙周炎（n=1052）的个体以及 2873 名健康对照个体进行了大样本分析。htSNP rs6681231 的罕见 G 等位基因与侵袭性牙周炎有关，在调整了吸烟、糖尿病和性别等混杂因素后，比值比为 1.57（95%置信区间 1.18-2.08；p=0.002）。htSNP rs6681231 对 rs20417 关联的验证为 COX-2 变体在牙周炎发病机制中的一般遗传风险提供了证据。
