片剂中盐酸罗匹尼罗的分光光度法测定

Spectrophotometric estimation of ropinirole hydrochloride in tablets.

作者信息

Shete Yogita, Pimpodkar Nayana, Nalawade R S, Pore Y V, Kuchekar B S

机构信息

Government College of Pharmacy, Vidyanagar, Karad-415 214, India.

出版信息

Indian J Pharm Sci. 2009 Jan;71(1):61-2. doi: 10.4103/0250-474X.51962.

DOI:10.4103/0250-474X.51962

PMID:20177460

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2810052/

Abstract

A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for estimation of ropinirole hydrochloride in bulk and tablet dosage forms. Ropinirole hydrochloride shows maximum absorbance at 250 nm with molar absorptivity of 8.703x10(3) l/mol.cm. Beer's law was obeyed in the concentration range of 5-35 mug/ml. Results of analysis were validated statistically and by recovery studies.

摘要

已开发出一种简单、灵敏、快速、准确且精密的分光光度法，用于测定原料药和片剂剂型中的盐酸罗匹尼罗。盐酸罗匹尼罗在250 nm处显示最大吸光度，摩尔吸光系数为8.703×10³ l/mol·cm。在5 - 35 μg/ml的浓度范围内符合比尔定律。分析结果通过统计学方法和回收率研究进行了验证。