紫外分光光度法同时测定盐酸氨溴索和盐酸左西替利嗪
Simultaneous UV Spectrophotometric Estimation of Ambroxol Hydrochloride and Levocetirizine Dihydrochloride.
作者信息
Prabhu S Lakshmana, Shirwaikar A A, Shirwaikar Annie, Kumar C Dinesh, Kumar G Aravind
机构信息
Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India.
出版信息
Indian J Pharm Sci. 2008 Mar-Apr;70(2):236-8. doi: 10.4103/0250-474X.41464.
Abstract
A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of ambroxol hydrochloride and levocetirizine dihydrochloride. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths 242 nm and 231 nm, the gamma max of ambroxol hydrochloride and levocetirizine dihydrochloride, respectively. Beer's law was obeyed in the concentration range 10-50 mug/ml and 8-24 mug/ml for ambroxol hydrochloride and levocetirizine dihydrochloride respectively. Results of the method were validated statistically and by recovery studies.
摘要
已开发出一种新颖、简单、灵敏且快速的分光光度法，用于同时测定盐酸氨溴索和盐酸左西替利嗪。该方法基于在两个波长（分别为盐酸氨溴索和盐酸左西替利嗪的最大吸收波长242 nm和231 nm）处测量吸光度来求解联立方程。盐酸氨溴索和盐酸左西替利嗪分别在10 - 50 μg/ml和8 - 24 μg/ml的浓度范围内符合比尔定律。该方法的结果通过统计学方法和回收率研究进行了验证。
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