Gahtori P, Das A, Bhatt H
Department of Pharmacy, Kumaun University, Bhimtal-263 136, India.
Indian J Pharm Sci. 2009 Jan;71(1):79-82. doi: 10.4103/0250-474X.51960.
In a wide search program towards new and efficient antibacterial agents, we assessed the extent to which physicochemical properties can be exploited to promote antibacterial activity associated with a series of substituted s-triazine. The synthesized compounds (1a-12b) were subsequently screened for their in vitro antibacterial activity against three gram positive (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus) and three Gram-negative microorganism (Salmonella typhi, Escherichia coli, Klebsiella aerogenes) by the broth dilution technique, recommended by European Committee for antimicrobial susceptibility testing with reference to streptomycin.
在一项针对新型高效抗菌剂的广泛研究计划中，我们评估了利用物理化学性质来促进一系列取代 s-三嗪的抗菌活性的程度。随后，通过肉汤稀释技术，参照链霉素，按照欧洲抗菌药物敏感性试验委员会推荐的方法，对合成的化合物（1a - 12b）针对三种革兰氏阳性菌（枯草芽孢杆菌、蜡样芽孢杆菌、金黄色葡萄球菌）和三种革兰氏阴性菌（伤寒沙门氏菌、大肠杆菌、产气克雷伯菌）进行了体外抗菌活性筛选。
