University of Colombo, 94, Cumaratunga Munidasa Mawatha, Colombo 03, Western Province Sri Lanka.
Indian J Microbiol. 2012 Mar;52(1):83-7. doi: 10.1007/s12088-011-0234-y. Epub 2011 Sep 16.
The continuing increase in the incidence of multi drug resistant pathogenic bacteria and shortage of new antimicrobial agents are the prime driver in efforts to identify the novel antimicrobial classes. In vitro antibacterial activity of 4-phenyl-1-(2-phenylallyl) pyridinium bromide was tested against Gram positive Staphylococcus aureus, Streptococcus species, Bacillus subtilis, and Gram negative Klebsiella aerogenes and Escherichia coli using disk diffusion method. Among them S. aureus showed strong antibacterial activity (21.99 ± 0.03 mm) while E. coli showed very little activity (8.97 ± 0.06 mm) towards the compound. The MIC of 4-phenyl-1-(2-phenyl-allyl)-pyridinium bromide for 90% S. aureus was ≤20 μg/ml and was compared with phenoxymethylpenicillin, cloxacillin, erythromycin and vancomycin. When 4-phenyl-1-(2-phenyl-allyl)pyridinium bromide showed MIC at ≤20 μg/ml, all others showed MIC at ≤100 μg/ml. Strong antibacterial activity of 4-phenyl-1-(2-phenyl-allyl)pyridinium bromide against S. aureus indicates that there is a possibility to use it as an effective antibacterial agent.
4-苯基-1-(2-苯丙烯基)吡啶溴化物对革兰氏阳性菌金黄色葡萄球菌、链球菌属、枯草芽孢杆菌和革兰氏阴性菌产气肠杆菌和大肠杆菌的体外抗菌活性采用纸片扩散法进行了测试。其中，金黄色葡萄球菌表现出很强的抗菌活性（21.99±0.03mm），而化合物对大肠杆菌的活性则非常低（8.97±0.06mm）。4-苯基-1-(2-苯丙烯基)吡啶溴化物对 90%金黄色葡萄球菌的 MIC 为≤20μg/ml，并与苯氧甲基青霉素、氯唑西林、红霉素和万古霉素进行了比较。当 4-苯基-1-(2-苯丙烯基)吡啶溴化物的 MIC 达到≤20μg/ml 时，其他所有药物的 MIC 均达到≤100μg/ml。4-苯基-1-(2-苯丙烯基)吡啶溴化物对金黄色葡萄球菌具有很强的抗菌活性，表明它有可能被用作有效的抗菌剂。
