印度出现普那霉素耐药性。
Emergence of pristinamycin resistance in India.
机构信息
Department of Pharmacology and Microbiology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India.
出版信息
Indian J Pharmacol. 2009 Feb;41(1):47-8. doi: 10.4103/0253-7613.48884.
Abstract
Quinupristin and dalfopristin combination has been advocated as a drug of choice for multi-drug resistant (MDR) gram-positive cocci (GPC). We are reporting two cases of neonatal septicemia, caused by the methicillin resistant Staphylococcus aureus (MRSA), showing primary in vitro pristinamycin resistance. The Minimum inhibitory concentrations (MIC) for pristinamycin in these two cases were 30 mug and 25 mug, respectively. Universal advocacy of pristinamycin for the therapy of MDR GPC infections should be re-evaluated.
摘要
奎奴普丁-达福普汀组合已被推荐为治疗多重耐药（MDR）革兰阳性球菌（GPC）的首选药物。我们报告了两例由耐甲氧西林金黄色葡萄球菌（MRSA）引起的新生儿败血症，这些病例均表现出初始体外普雷霉素耐药性。这两例的普雷霉素最低抑菌浓度（MIC）分别为 30 微克和 25 微克。应重新评估普雷霉素作为治疗 MDR GPC 感染的普遍应用。
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