胎儿及新生儿肝脏中的金属硫蛋白、铜和锌：发育过程中的变化

Metallothionein, copper and zinc in fetal and neonatal human liver: changes during development.

作者信息

Klein D, Scholz P, Drasch G A, Müller-Höcker J, Summer K H

机构信息

GSF-Institut für Toxikologie, Neuherberg, F.R.G.

出版信息

Toxicol Lett. 1991 Apr;56(1-2):61-7. doi: 10.1016/0378-4274(91)90090-s.

DOI:10.1016/0378-4274(91)90090-s

PMID:2017784

Abstract

Total and cytosolic zinc (Zn) and copper (Cu), cytosolic metallothionein (MT) and the Cu-load of MT were investigated in fetal (22, 24 and 32 gestational weeks) and neonatal (2-15 months) human liver. Whereas the fraction of cytosolic Zn remained constant at 66% of the total independent of the stage of development, the fraction of cytosolic Cu increased from 26% in preterm liver to about 100% within 12 months postnatally. The MT content was higher in fetal than in neonatal liver. There was a linear correlation (r = 0.996) between cytosolic MT and Zn in both fetal and neonatal liver but not between MT and Cu. In contrast to fetal liver, the Cu-load of MT in neonatal liver seems to be determined by the Zn/Cu ratio in the cytosol. The results suggest that MT is involved in the regulation of Cu and Zn metabolism during fetal and neonatal development.

摘要

对胎儿（妊娠22、24和32周）和新生儿（2至15个月）的人类肝脏中的总锌（Zn）和胞质锌、总铜（Cu）和胞质铜、胞质金属硫蛋白（MT）以及MT的铜负荷进行了研究。尽管胞质锌的比例在发育阶段独立时保持在总锌的66%不变，但胞质铜的比例从早产肝脏中的26%在出生后12个月内增加到约100%。胎儿肝脏中的MT含量高于新生儿肝脏。在胎儿和新生儿肝脏中，胞质MT与Zn之间存在线性相关性（r = 0.996），但MT与Cu之间不存在线性相关性。与胎儿肝脏不同，新生儿肝脏中MT的铜负荷似乎由胞质中的Zn/Cu比值决定。结果表明，MT参与了胎儿和新生儿发育过程中铜和锌代谢的调节。