Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA.
Ethn Dis. 2010 Winter;20(1):11-4.
Prior research found reduced mortality in coronary heart patients with higher scores on the Openness to Experience domain and its facets. Decreased C-reactive protein level (CRP) levels may be one mechanism by which higher Openness to Experience leads to decreased mortality. Thus, the current study aimed to test the association between the Openness to Experience domain and its facets, as assessed by the NEO Personality Inventory-Revised, and CRP in a sample of 165 healthy Black and White, male and female community volunteers.
Blood samples were taken before and after a 40-minute mental stress protocol. BMI and education were significant predictors of CRP and, in addition to age, were included as covariates in all analyses. Race and sex were tested as possible moderating variables.
In a mixed effects model the main effect of time (pre/post-stress), Openness to Experience (O) and their interaction were not significant predictors of CRP. However, results showed a significant race x O effect on CRP (P=.03). In Blacks, higher Openness to Experience domain (r=-.41, P<.01), aesthetics facet (r=-.30, P=.01), feelings facet (r= -.41, P<.01), and ideas facet (r=-.38, P<.01) scores were associated with lower mean CRP levels. In contrast, among White participants, neither the Openness to Experience domain nor its related facets were associated with CRP.
The Openness to Experience domain and its facets may be associated with markers of the inflammatory process among Blacks but not Whites.
先前的研究发现，在冠心病患者中，开放性体验得分较高及其各方面得分较高的患者死亡率较低。C 反应蛋白（CRP）水平降低可能是开放性体验程度较高导致死亡率降低的一种机制。因此，本研究旨在测试 NEO 人格量表修订版评估的开放性体验领域及其各方面与 CRP 在 165 名健康的黑人和白人、男性和女性社区志愿者样本中的相关性。
在进行 40 分钟的心理压力测试前后采集血样。BMI 和教育程度是 CRP 的显著预测因素，除年龄外，所有分析均将其作为协变量纳入。种族和性别被测试为可能的调节变量。
在混合效应模型中，时间（前后压力）、开放性体验（O）及其相互作用的主效应不是 CRP 的显著预测因素。然而，结果显示 CRP 存在显著的种族 x O 效应（P=.03）。在黑人中，较高的开放性体验领域（r=-.41，P<.01）、审美方面（r=-.30，P=.01）、情感方面（r=-.41，P<.01）和想法方面（r=-.38，P<.01）得分与较低的平均 CRP 水平相关。相比之下，在白人参与者中，开放性体验领域及其相关方面均与 CRP 无关。
开放性体验领域及其各方面可能与黑人的炎症过程标志物相关，但与白人无关。
