Lab. Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Mutat Res. 2010 Apr-Jun;704(1-3):200-5. doi: 10.1016/j.mrrev.2010.02.003. Epub 2010 Feb 21.
In this review, an overview of intensity-modulated radiotherapy (IMRT) and related high precision radiation techniques is presented. In addition, the related radiobiological issues are discussed. Hereby, we try to point to the potential differences in radiobiological effect between popular intensity-modulated radiotherapy and related techniques (IMRT+) and conventional or three-dimensional radiotherapy (3D-RT). Further, an overview of the existing in vitro and in vivo radiobiological models to investigate the effect of spatially and/or temporally fractionated dose distributions, as applied in IMRT+, on the biological outcome is given. More in detail, our radiobiological models will be presented. Additionally, we will discuss the (dis)advantages of the presented models, and give some consideration to improve the existing radiobiological models in terms of set-up and clinical relevance.
在这篇综述中，介绍了强度调制放疗（IMRT）和相关的高精度放射技术。此外，还讨论了相关的放射生物学问题。在这里，我们试图指出在流行的强度调制放疗和相关技术（IMRT+）与传统或三维放疗（3D-RT）之间放射生物学效应的潜在差异。此外，还概述了现有的体外和体内放射生物学模型，以研究在 IMRT+中应用的空间和/或时间分割剂量分布对生物学结果的影响。更详细地说，我们将介绍放射生物学模型。此外，我们还将讨论所提出模型的优缺点，并考虑在设置和临床相关性方面改进现有的放射生物学模型。
