Kaļva Kalvis, Zdanovskis Nauris, Šneidere Kristīne, Kostiks Andrejs, Karelis Guntis, Platkājis Ardis, Stepens Ainārs
Department of Radiology, Riga Stradins University, LV-1007 Riga, Latvia.
Department of Radiology, Riga East Clinical University Hospital, LV-1038 Riga, Latvia.
Diagnostics (Basel). 2023 Dec 16;13(24):3679. doi: 10.3390/diagnostics13243679.
Diffusion tensor imaging (DTI) is an MRI analysis method that could help assess cognitive impairment (CI) in the ageing population more accurately. In this research, we evaluated fractional anisotropy (FA) of whole brain (WB) and corpus callosum (CC) in patients with normal cognition (NC), mild cognitive impairment (MCI), and moderate/severe cognitive impairment (SCI). In total, 41 participants were included in a cross-sectional study and divided into groups based on Montreal Cognitive Assessment (MoCA) scores (NC group, nine participants, MCI group, sixteen participants, and SCI group, sixteen participants). All participants underwent an MRI examination that included a DTI sequence. FA values between the groups were assessed by analysing FA value and age normative percentile. We did not find statistically significant differences between the groups when analysing CC FA values. Both approaches showed statistically significant differences in WB FA values between the MCI-SCI and MCI-NC groups, where the MCI group participants showed the highest mean FA and highest mean FA normative percentile results in WB.
扩散张量成像（DTI）是一种磁共振成像（MRI）分析方法，它有助于更准确地评估老年人群的认知障碍（CI）。在本研究中，我们评估了认知正常（NC）、轻度认知障碍（MCI）和中度/重度认知障碍（SCI）患者全脑（WB）和胼胝体（CC）的分数各向异性（FA）。共有41名参与者纳入一项横断面研究，并根据蒙特利尔认知评估（MoCA）分数分为几组（NC组，9名参与者；MCI组，16名参与者；SCI组，16名参与者）。所有参与者均接受了包括DTI序列的MRI检查。通过分析FA值和年龄标准化百分位数来评估各组之间的FA值。分析CC的FA值时，我们未发现各组之间存在统计学上的显著差异。两种方法均显示，MCI-SCI组与MCI-NC组之间的WB FA值存在统计学上的显著差异，其中MCI组参与者在WB中的平均FA和平均FA标准化百分位数结果最高。
