Apostolski S, Nikolić J, Bugarski-Prokopljević C, Miletić V, Pavlović S, Filipović S
Department of Neurology, University Clinical Centre, Belgrade, Yugoslavia.
Acta Neurol Scand. 1991 Feb;83(2):96-8. doi: 10.1111/j.1600-0404.1991.tb04656.x.
Serum and CSF immunological findings were analysed in 37 patients with amyotrophic lateral sclerosis (ALS). ALS patients had significantly higher mean values of serum IgG and complement component C4 and significantly lower mean value of total haemolytic titre of complement (THC) compared with normal controls. Incidence of immune complexes (ICs) was significantly higher in sera of ALS patients than in normal controls. There was no significant difference regarding mean serum levels of IgM, IgA, and complement components C3 and Factor B between patients and controls. The blood-brain barrier (BBB) damage was found in 46% of patients. Intrathecal IgG synthesis was detected in six patients (16%). These results support the hypothesis of immune system involvement in ALS.
对37例肌萎缩侧索硬化症（ALS）患者的血清和脑脊液免疫学结果进行了分析。与正常对照组相比，ALS患者血清IgG和补体成分C4的平均值显著更高，而补体总溶血活性（THC）的平均值显著更低。ALS患者血清中免疫复合物（ICs）的发生率显著高于正常对照组。患者与对照组之间IgM、IgA以及补体成分C3和B因子的血清平均水平无显著差异。46%的患者存在血脑屏障（BBB）损伤。6例患者（16%）检测到鞘内IgG合成。这些结果支持免疫系统参与ALS的假说。
