通过信号抑制调节肿瘤血管生成以改善细胞毒性治疗。
Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy.
机构信息
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Cancer Res. 2010 Mar 15;70(6):2141-5. doi: 10.1158/0008-5472.CAN-09-3615. Epub 2010 Feb 23.
Abstract
The tumor microenvironment is a key factor in cancer treatment response. Recent work has shown that changes in the tumor vasculature can be achieved by inhibiting tumor cell signaling, resulting in enhanced tumor oxygenation. These changes could promote responses to both chemo- and radiation therapy.
摘要
肿瘤微环境是癌症治疗反应的一个关键因素。最近的研究表明，通过抑制肿瘤细胞信号转导可以实现肿瘤血管的改变，从而增强肿瘤的氧合作用。这些变化可以促进化疗和放疗的反应。
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