Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Endocr J. 2010;57(4):339-45. doi: 10.1507/endocrj.k09e-359. Epub 2010 Feb 24.
The effect of stress associated with acute weight reduction on adipocytokine production is incompletely understood. In the present study, we have investigated the changes in circulating adipocytokine concentrations and urinary concentrations of stress markers in male collegiate wrestlers during acute weight reduction for a competition. Twenty healthy Japanese male wrestlers (18-22 years of age) who participated in the national collegiate wrestling tournament were studied. Body weight, body fat amount, serum testosterone, serum leptin, serum adiponectin, urinary 8-hydroxy-2'- deoxyguanosine (8-OHdG) and urinary biopyrrins were analyzed during acute weight reduction for the competition. Body weight, body fat amount and the serum concentrations of testosterone, leptin and adiponectin significantly decreased on the day of weigh-in compared with the levels 12 days before weigh-in. In contrast, urinary concentrations of 8-OHdG and biopyrrins significantly increased on the day of weigh-in compared with the concentrations 12 days before weigh-in. A positive correlation was observed between the serum concentrations of adiponectin and testosterone, and a negative correlation was observed between the concentrations of serum adiponectin and urinary biopyrrins. The present results suggest that rapid weight reduction increases the urinary concentrations of stress markers, which is associated with a decrease in serum concentrations of adiponectin.
急性体重减轻引起的应激对脂肪细胞因子产生的影响尚不完全清楚。在本研究中，我们研究了 20 名参加全国大学生摔跤锦标赛的健康的日本男性摔跤运动员在为比赛进行急性体重减轻期间循环脂肪细胞因子浓度和应激标志物尿浓度的变化。在比赛期间进行急性体重减轻时，分析了体重、体脂量、血清睾酮、血清瘦素、血清脂联素、尿 8-羟基-2'-脱氧鸟苷（8-OHdG）和尿粪卟啉的浓度。与 12 天前称重时相比，称重当天体重、体脂量和血清睾酮、瘦素和脂联素浓度显著降低。相比之下，称重当天尿 8-OHdG 和粪卟啉浓度与 12 天前相比显著升高。血清脂联素和睾酮浓度呈正相关，血清脂联素浓度与尿粪卟啉浓度呈负相关。这些结果表明，快速减重会增加尿应激标志物的浓度，这与血清脂联素浓度降低有关。
