Department of Glaucoma, Pushpagiri Eye Institute, West Marredpally, Secunderabad, Andhra Pradesh, India.
J Glaucoma. 2010 Dec;19(9):604-8. doi: 10.1097/IJG.0b013e3181d12e03.
To evaluate correlation between peripapillary retinal nerve fiber layer thickness (RNFL) and optic nerve head (ONH) parameters in normal participants using Spectral domain optical coherence tomography (OCT).
Sixty-five eyes of 65 healthy participants aged 13-79 years underwent ONH analysis and peripapillary RNFL thickness measurements using spectral domain OCT. The RNFL measurements were correlated with the data obtained with ONH analysis.
The average and quadrant RNFL thickness did not show correlation with optic disc area. A positive correlation was found between average RNFL thickness and rim area (r=0.425, P=0.000) and negative correlation between average RNFL thickness and cup area (r=-0.249, P<0.046).
In our study, peripapillary RNFL thickness as measured by OCT did not show correlation with optic disc size. Despite a shorter distance between optic disc and circular scan margin, larger discs did not show a thicker RNFL. Interindividual variability of disc area probably minimizes the effect of various ONH size on RNFL thickness measurement.
利用频域光学相干断层扫描（OCT）评估正常受试者的视盘周围视网膜神经纤维层（RNFL）厚度和视盘（ONH）参数之间的相关性。
65 名 13-79 岁健康受试者的 65 只眼接受了 ONH 分析和频域 OCT 下的视盘周围 RNFL 厚度测量。将 RNFL 测量值与 ONH 分析获得的数据进行相关性分析。
平均和象限 RNFL 厚度与视盘面积无相关性。平均 RNFL 厚度与边缘面积呈正相关（r=0.425，P=0.000），与杯面积呈负相关（r=-0.249，P<0.046）。
在我们的研究中，OCT 测量的视盘周围 RNFL 厚度与视盘大小无关。尽管视盘和圆形扫描边缘之间的距离较短，但较大的视盘并不显示较厚的 RNFL。视盘面积的个体间变异性可能使各种 ONH 大小对视盘周围 RNFL 厚度测量的影响最小化。
