Devers Eye Institute, Portland, Oregon, USA.
Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):394-405. doi: 10.1167/iovs.11-8244.
To test whether the enhanced depth imaging (EDI) modality improves anterior and posterior lamina cribrosa surface (ALCS and PLCS) visibility compared with conventional spectral-domain optical coherence tomography (SD-OCT).
Conventional and EDI SD-OCT scans were obtained 30 minutes after IOP was manometrically lowered to 10 mm Hg in both eyes of 14 nonhuman primates (NHPs) with unilateral experimental glaucoma (EG). Thirteen horizontal and seven vertical radial B-scans of each SD-OCT data set were delineated by one operator masked to image type. Delineated ALCS and PLCS points were projected to 1 of 100 equal-sized subregions of the neural canal opening (NCO) reference plane, and the number of delineated subregions (≥2 points) was counted. Poisson regression was used to analyze the effects of image type, treatment, and quadrant. Two additional delineations were performed for three NHPs to compare reproducibility.
EDI increased the number of subregions delineated for both the ALCS (by 28%; P < 0.0001) and PLCS (by 225%; P < 0.0001). EDI improvement in ALCS visibility was significant in the superior quadrant only and was not different in EG versus control eyes, whereas EDI improvement in PLCS visibility was significant in all four quadrants (P < 0.005) and greater in EG eyes (P < 0.001), nasally and temporally. Intradelineator reproducibility was not different between image types. EDI and standard ONH parameter values were similar except for PLCS depth which was deeper in the EDI data sets (P = 0.0002).
ALCS and PLCS visibility within control and EG NHP ONHs increased in EDI compared to conventional SD-OCT data sets. Further study of EDI effects on PLCS parameterization is required.
测试增强深度成像（EDI）模式是否比传统的光谱域光学相干断层扫描（SD-OCT）更能提高前、后小梁筛板表面（ALCS 和 PLCS）的可视性。
在 14 只单侧实验性青光眼（EG）的非人类灵长类动物（NHP）的双眼中，通过眼压计将眼压降低至 10mmHg 30 分钟后，获得了常规和 EDI SD-OCT 扫描。由一位对图像类型不知情的操作人员，对每个 SD-OCT 数据集的 13 个水平和 7 个垂直径向 B 扫描进行了描绘。将描绘的 ALCS 和 PLCS 点投影到神经管开口（NCO）参考平面的 100 个等大小子区域中的 1 个，并计算出描绘的子区域数量（≥2 个点）。采用泊松回归分析图像类型、治疗和象限的影响。对 3 只 NHP 进行了另外两次描绘，以比较重现性。
EDI 增加了 ALCS（增加了 28%；P < 0.0001）和 PLCS（增加了 225%；P < 0.0001）的可描绘子区域数量。仅在上方象限中，EDI 提高了 ALCS 的可视性，并且在 EG 与对照眼之间没有差异，而在所有四个象限中（P < 0.005），并且在 EG 眼中（P < 0.001），EDI 提高了 PLCS 的可视性，鼻侧和颞侧更为明显。在图像类型之间，划线者的重现性没有差异。EDI 和标准 ONH 参数值相似，除了 EDI 数据集的 PLCS 深度更深（P = 0.0002）。
与传统的 SD-OCT 数据集相比，在 EDI 中，控制和 EG 灵长类动物的 ONH 中的 ALCS 和 PLCS 可视性增加。需要进一步研究 EDI 对 PLCS 参数化的影响。
