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芳香酶抑制剂相关关节痛的处理。

Management of aromatase inhibitor-induced arthralgia.

出版信息

Curr Oncol. 2010 Feb;17(1):87-90. doi: 10.3747/co.v17i1.474.

DOI:10.3747/co.v17i1.474
PMID:20179809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2826784/
Abstract

Aromatase inhibitors (AIs) are commonly used as adjuvant treatment in postmenopausal women with hormone receptor-positive early breast cancer. With both steroidal and nonsteroidal AIs, AI-induced arthralgia is frequently observed. The mechanism of AI-induced arthralgia remains unknown, and the data available from clinical trails using AIs are limited. We review the pertinent information from a clinical perspective, including an algorithm to treat AI-induced arthralgia.

摘要

芳香酶抑制剂 (AIs) 常用于治疗绝经后激素受体阳性早期乳腺癌的辅助治疗。甾体和非甾体 AIs 均可引起关节痛。AI 引起的关节痛的机制尚不清楚，且 AI 临床试验的可用数据有限。我们从临床角度综述了相关信息，包括治疗 AI 引起的关节痛的算法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b624/2826784/b8df921810c3/conc17-1-87f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b624/2826784/b8df921810c3/conc17-1-87f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b624/2826784/b8df921810c3/conc17-1-87f1.jpg

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J Clin Oncol. 2008 Jul 1;26(19):3147-52. doi: 10.1200/JCO.2007.15.4005. Epub 2008 May 12.
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Hydrotherapy versus conventional land-based exercise for the management of patients with osteoarthritis of the knee: a randomized clinical trial.水疗法与传统陆地运动对膝骨关节炎患者的管理效果比较：一项随机临床试验
Phys Ther. 2008 Jan;88(1):12-21. doi: 10.2522/ptj.20060040. Epub 2007 Nov 6.
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Prevalence of joint symptoms in postmenopausal women taking aromatase inhibitors for early-stage breast cancer.
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Sci Rep. 2021 Jul 21;11(1):14843. doi: 10.1038/s41598-021-94466-0.
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