Graduate Institute of Integrated Medicine, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Sci Rep. 2021 Jul 21;11(1):14843. doi: 10.1038/s41598-021-94466-0.
Aromatase inhibitors (AIs) are standard adjuvant therapy for postmenopausal women with oestrogen receptor-positive, early-stage, and metastatic breast cancer. Although effective, the risk of falls due to AI-associated knee joint pain significantly increased. The aim of this study was to evaluate the therapeutic effects of yoga and massage on AI-associated knee joint pain. Breast cancer survivors were randomly assigned to a 6-week yoga intervention-2-week rest-6-week massage exposure (Yoga first, n = 30) or a 6-week massage intervention-2-week rest-6-week yoga exposure (Massage first, n = 30). Evaluations of the treatment efficacy were made at baseline, post-intervention, and post-exposure using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale, plasma cytokine levels, and changes in meridian energy. The results showed that yoga, superior to massage intervention, significantly reduced AI-associated knee joint pain, as demonstrated by the WOMAC pain score. The yoga intervention improvements were also associated with changes in plasma cytokine levels and meridian energy changes. In conclusion, this study provides scientific evidence that yoga was more effective than massage for reducing AI-associated knee joint pain. Meridian energy changes may provide another scientific, objective, non-invasive way to monitor the therapeutic effects of yoga and investigate another alternative, complementary medicine.
芳香化酶抑制剂（AIs）是治疗绝经后雌激素受体阳性、早期和转移性乳腺癌患者的标准辅助治疗药物。尽管有效，但由于 AI 相关的膝关节疼痛，跌倒的风险显著增加。本研究旨在评估瑜伽和按摩对 AI 相关膝关节疼痛的治疗效果。乳腺癌幸存者被随机分配到为期 6 周的瑜伽干预-2 周休息-6 周按摩暴露（瑜伽优先，n = 30）或 6 周按摩干预-2 周休息-6 周瑜伽暴露（按摩优先，n = 30）。使用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）量表、血浆细胞因子水平和经络能量变化，在基线、干预后和暴露后评估治疗效果。结果表明，瑜伽优于按摩干预，可显著减轻 AI 相关的膝关节疼痛，WOMAC 疼痛评分显示。瑜伽干预的改善也与血浆细胞因子水平和经络能量变化有关。总之，本研究提供了科学证据，表明瑜伽比按摩更能减轻 AI 相关的膝关节疼痛。经络能量变化可能为监测瑜伽的治疗效果提供另一种科学、客观、非侵入性的方法，并研究另一种替代、补充医学。
