Suppr超能文献

台湾地区 7 个人群的 17 个 Y 染色体短串联重复序列单倍型。

Seventeen Y-chromosomal short tandem repeat haplotypes in seven groups of population living in Taiwan.

机构信息

Department and Graduate Institute of Forensic Medicine, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan.

出版信息

Int J Legal Med. 2010 Jul;124(4):295-300. doi: 10.1007/s00414-010-0425-9. Epub 2010 Feb 24.

Abstract

The analysis of Y-chromosome short tandem repeat (Y-STR) loci is a powerful tool in forensic casework. The aim of this study was to present the 17 Y-STR loci haplotype distributions of groups of population living in Taiwan and to demonstrate genetic distances between the groups as well as multidimensional scaling plot based on Y-STR genotype data. Five hundred and fifteen DNA samples from unrelated males of seven groups of population, including Taiwanese Han, two groups of indigenous Taiwanese of Taiwan Island, Tao, mainland Chinese, Filipinos, and a group of people with European, Near Eastern, or South Asian ancestry, were analyzed using a commercial kit that co-amplifies 17 Y-STRs. A total of 471 different haplotypes with 440 unique haplotypes were identified. The overall haplotype diversity was 0.9995 +/- 0.0002. High haplotype diversity was observed in six groups of population, except the Tao. These Y-STRs revealed a low discrimination capacity in the Tao population (36.84%), which should be considered in forensic practice. The multidimensional scaling plot of these seven groups of population constructed based on the genetic distances according to 17 Y-STR loci presented a clear patrilineal genetic substructure in the area. Partial Y-STRs profiling reduced the discrimination capacity in most groups of population and distorted the multidimensional scaling plot.

摘要

Y 染色体短串联重复序列(Y-STR)分析是法医学中的有力工具。本研究旨在介绍生活在台湾的人群的 17 个 Y-STR 位点单倍型分布,并展示群体之间的遗传距离以及基于 Y-STR 基因型数据的多维尺度图。使用商业试剂盒对来自台湾汉族、台湾岛的两个台湾原住民群体、Tao、中国大陆人、菲律宾人和具有欧洲、近东或南亚血统的人群的 7 个无关男性群体的 515 个 DNA 样本进行分析,该试剂盒共同扩增 17 个 Y-STR。共鉴定出 471 种不同的单倍型,其中 440 种为独特的单倍型。总体单倍型多样性为 0.9995 +/- 0.0002。除 Tao 外,六个群体的单倍型多样性较高。这些 Y-STR 在 Tao 人群中显示出较低的鉴别能力(36.84%),在法医学实践中应予以考虑。根据 17 个 Y-STR 位点的遗传距离构建的这七个群体的多维尺度图显示了该地区明显的父系遗传亚结构。部分 Y-STR 分析降低了大多数群体的鉴别能力,并扭曲了多维尺度图。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验