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亲缘系数的估计:短期遗传距离的基础。

Estimation of the coancestry coefficient: basis for a short-term genetic distance.

机构信息

Department of Statistics, North Carolina State University, Raleigh, North Carolina 27650.

出版信息

Genetics. 1983 Nov;105(3):767-79. doi: 10.1093/genetics/105.3.767.

Abstract

A distance measure for populations diverging by drift only is based on the coancestry coefficient theta, and three estimators of the distance D = -ln(1 - theta) are constructed for multiallelic, multilocus data. Simulations of a monoecious population mating at random showed that a weighted ratio of single-locus estimators performed better than an unweighted average or a least squares estimator. Jackknifing over loci provided satisfactory variance estimates of distance values. In the drift situation, in which mutation is excluded, the weighted estimator of D appears to be a better measure of distance than others that have appeared in the literature.

摘要

一个仅由漂变引起的群体间的距离度量是基于共祖系数θ的,并且针对多等位基因、多位点数据构建了三个距离估计值 D = -ln(1 - θ)的估计量。模拟一个雌雄同花的随机交配群体的结果表明,单一位点估计量的加权比值表现优于未加权平均值或最小二乘法估计量。对位点进行的刀切法提供了距离值的满意方差估计。在排除突变的漂变情况下,加权估计量 D 似乎是比文献中出现的其他距离度量更好的度量。

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