Division of Endocrinology Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, 15 North 2030 East, Bldg. 533 Room 3110B, Salt Lake City, UT 84112, USA.
Rev Endocr Metab Disord. 2010 Mar;11(1):31-9. doi: 10.1007/s11154-010-9131-7.
Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better understanding of its pathophysiology is necessary for early diagnosis and the development of treatment strategies for diabetes-associated cardiovascular dysfunction. We will review recent basic and clinical research into the manifestations and the pathophysiological mechanisms of diabetic cardiomyopathy. The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models.
糖尿病与心力衰竭的发生率增加有关，即使在控制了冠状动脉疾病和高血压之后也是如此。因此，随着糖尿病心肌病在临床医生中成为一种越来越被认可的实体，为了早期诊断和制定与糖尿病相关的心血管功能障碍的治疗策略，更好地了解其病理生理学是必要的。我们将回顾最近关于糖尿病心肌病的临床表现和病理生理机制的基础和临床研究。讨论将集中在糖尿病中心肌发生的结构、功能和代谢变化，以及这些变化如何导致受影响的人类和相关动物模型中糖尿病心肌病的发展。
