School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.
Int J Comput Assist Radiol Surg. 2010 Sep;5(5):471-87. doi: 10.1007/s11548-010-0405-z. Epub 2010 Feb 24.
There is a need for methods which enable precise correlation of histologic sections with in vivo prostate images. Such methods would allow direct comparison between imaging features and functional or histopathological heterogeneity of tumors. Correlation would be particularly useful for validating the accuracy of imaging modalities, developing imaging techniques, assessing image-guided therapy, etc. An optimum prostate slicing method for accurate correlation between the histopathological and medical imaging planes in terms of section angle, thickness and level was sought.
Literature review (51 references from 1986-2009 were cited) was done on the various sectioning apparatus or techniques used to slice the prostate specimen for accurate correlation between histopathological data and medical imaging. Technology evaluation was performed with review and discussion of various methods used to section other organs and their possible applications for sectioning prostatectomy specimens.
No consensus has been achieved on how the prostate should be dissected to achieve a good correlation. Various customized sectioning instruments and techniques working with different mechanism are used in different research institutes to improve the correlation. Some of the methods have convincingly shown significant potential for improving image-specimen correlation. However, the semisolid consistent property of prostate tissue and the lack of identifiable landmarks remain challenges to be overcome, especially for fresh prostate sectioning and microtomy without external fiducials.
A standardized optimum protocol to dissect prostatectomy specimens is needed for the validation of medical imaging modalities by histologic correlation. These standards can enhance disease management by improving the comparability between different modalities.
需要有一种方法能够精确地将组织学切片与体内前列腺图像相关联。这种方法将允许在成像特征与肿瘤的功能或组织病理学异质性之间进行直接比较。相关性对于验证成像方式的准确性、开发成像技术、评估图像引导治疗等特别有用。本研究旨在寻求一种最优的前列腺切片方法，以在切片角度、厚度和水平方面实现组织病理学和医学成像平面之间的精确相关。
对用于为准确关联组织病理学数据和医学成像而对前列腺标本进行切片的各种切片设备或技术进行了文献回顾（引用了 1986 年至 2009 年的 51 篇参考文献）。通过对用于对其他器官进行切片的各种方法的回顾和讨论，对技术进行了评估，并探讨了它们在前列腺切除术标本切片中的可能应用。
对于如何进行前列腺解剖以实现良好的相关性，尚未达成共识。不同的研究机构使用各种定制的切片仪器和技术，这些技术的工作原理不同，以提高相关性。一些方法已经令人信服地显示出了显著提高图像-标本相关性的潜力。然而，前列腺组织的半固态一致性特性和缺乏可识别的标志仍然是需要克服的挑战，尤其是对于没有外部基准的新鲜前列腺切片和微切术。
需要制定一种标准化的最佳方案来解剖前列腺切除术标本，以便通过组织学相关性验证医学成像方式。这些标准可以通过提高不同方式之间的可比性来改善疾病管理。
