2001 年至 2007 年兰州地区儿童腹泻病中人杯状病毒感染的流行病学研究。

Epidemiological study of human calicivirus infection in children with gastroenteritis in Lanzhou from 2001 to 2007.

机构信息

School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

出版信息

Arch Virol. 2010 Apr;155(4):553-5. doi: 10.1007/s00705-010-0592-5. Epub 2010 Feb 24.

PMID:20180141

Abstract

Stool specimens were collected from 1,195 young children with acute diarrhea in Lanzhou, China, from 2001 to 2007. RT-PCR was used to detect human calicivirus (HucV). One hundred seventeen specimens were found positive for HucV. The infection rate was noticeably higher during 2006-2007 compared to the other years studied. Ninety-six specimens were sequenced to determine the genotypes of HucV. Eighty-six were norovirus and 10 were sapovirus, while GII/4 was the predominant strain of NV, followed by GII/3. The subtype of NV GII/4 changed from the Farmington Hills strain to the Bristol strain, and then to the Hunter strain and variant 2006b strain, over time. Variant 2006b has become the major epidemic strain in Lanzhou and should be closely monitored in the coming years.

摘要

2001 年至 2007 年，从中国兰州 1195 例急性腹泻的幼儿中采集粪便标本。采用 RT-PCR 法检测人杯状病毒（HucV）。117 份标本 HucV 阳性。与研究的其他年份相比，2006-2007 年的感染率明显更高。对 96 个标本进行测序以确定 HucV 的基因型。86 个为诺如病毒，10 个为肠腺病毒，其中 GII/4 是 NV 的主要流行株，其次是 GII/3。随着时间的推移，NV GII/4 的亚型从法明顿山株变为布里斯托株，再变为亨特株和 2006b 变异株。2006b 变异株已成为兰州的主要流行株，在未来几年应密切监测。