Department of Gastroenterology, Huizhou Municipal Central Hospital, Huizhou 516001, Guangdong Province, China.
World J Gastroenterol. 2010 Feb 28;16(8):960-5. doi: 10.3748/wjg.v16.i8.960.
To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province, China.
A review of patient records from 1986 to 2006 from five hospitals was conducted. Patient data was obtained, including age, gender, location of lesions, staging and histological type of CRC. The Chi-square test was used to assess differences in rates and a significance level of 0.05 was used. Univariate comparisons were made via Fisher's exact tests.
Analysis was carried out on 8172 CRC patents, 6.1% (499/8172) of the patients were aged < or = 30 years. The peak incidence was between the ages 61-70 years (27.8%). The mean age at CRC diagnosis increased from 52 years (1986-1988) to 60 years (2004-2006) and the proportion of young CRC patients decreased from 8.0% to 5.9% over the same period. Of 8172 lesions, 4434 (54.3%) were located in rectum and 3738 (45.7%) in colon. The incidence of rectal cancer decreased significantly from 59.4% (1989-1991) to 51.8% (2004-2006) and right sided colon cancer increased from 40.6% to 48.2%. The mean age, anatomic distribution, histological type and differentiation degree were significantly different among the four geographical areas (P < 0.05).
The hospitalization rate for CRC has increased in Guangdong in recent years. The characteristics of CRC from the five hospitals located in the four different areas of Guangdong Province are also different. Further studies are needed to assess more recent trend in the incidence and prevalence of CRC as well as the respective roles of genetic and environmental factors in CRC.
确定中国广东省四个不同地区的五家医院结直肠癌（CRC）的基本人口统计学特征。
对五家医院 1986 年至 2006 年的患者病历进行了回顾性分析。获取了患者的数据，包括年龄、性别、病变部位、CRC 的分期和组织学类型。采用卡方检验评估率的差异，显著性水平为 0.05。采用 Fisher 确切检验进行单变量比较。
对 8172 例 CRC 患者进行了分析，其中 6.1%（499/8172）的患者年龄≤30 岁。发病高峰年龄为 61-70 岁（27.8%）。CRC 诊断时的平均年龄从 52 岁（1986-1988 年）增加到 60 岁（2004-2006 年），同期年轻 CRC 患者的比例从 8.0%下降到 5.9%。在 8172 个病变中，4434 个（54.3%）位于直肠，3738 个（45.7%）位于结肠。直肠癌的发病率从 59.4%（1989-1991 年）显著下降到 51.8%（2004-2006 年），右侧结肠癌从 40.6%增加到 48.2%。四个地理区域之间的平均年龄、解剖分布、组织学类型和分化程度均有显著差异（P<0.05）。
近年来，广东 CRC 的住院率有所增加。广东四个不同地区五家医院的 CRC 特征也不同。需要进一步研究以评估 CRC 的发病率和患病率的最新趋势，以及遗传和环境因素在 CRC 中的各自作用。
