Lee Sang Yup
Department of Chemical and Biomolecular Engineering (BK21 Program), BioProcess Engineering Research Center, Bioinformatics Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon 305-701, Korea.
Genome Inform. 2009 Oct;23(1):214-6.
Systems biology has been changing the way biological and biotechnological research is performed. Now, systems biological approaches can be taken to develop bioprocesses for the production of valuable drugs, commodity and fine chemicals, fuels, and polymers and other materials; this is termed systems biotechnology. Here I present the general strategies for systems biotechnology and several examples of applying systems biotechnological strategies for the development of bioprocesses for the efficient production of chemicals and materials. This also includes a strategy of systems metabolic engineering for the development of microbial strains. It is expected that systems biotechnology will be at the heart of successful industrial biotechnology towards low carbon green growth of the world.
系统生物学一直在改变生物学和生物技术研究的开展方式。如今，可以采用系统生物学方法来开发用于生产有价值药物、商品和精细化学品、燃料、聚合物及其他材料的生物过程；这被称为系统生物技术。在此，我介绍系统生物技术的一般策略，以及应用系统生物技术策略开发高效生产化学品和材料的生物过程的几个实例。这还包括用于开发微生物菌株的系统代谢工程策略。预计系统生物技术将成为实现世界低碳绿色增长的成功工业生物技术的核心。
