一种酶可能如何加速分子内 Diels-Alder 反应：合成 Salvileucalin B 的拟酶。
How an enzyme might accelerate an intramolecular Diels-Alder reaction: theozymes for the formation of salvileucalin B.
机构信息
Department of Chemistry, University of California-Davis, 1 Shields Avenue, Davis, California 95616, USA.
出版信息
Org Lett. 2010 Mar 19;12(6):1164-7. doi: 10.1021/ol9028435.
PMID:20180530
Abstract
Quantum chemical calculations reveal how functional group arrays present in known enzyme active sites could accelerate an intramolecular Diels-Alder reaction proposed to occur during the biosynthesis of a complex terpenoid natural product.
摘要
量子化学计算揭示了已知酶活性位点中存在的官能团阵列如何加速拟发生在复杂萜类天然产物生物合成过程中的分子内 Diels-Alder 反应。
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